| Title |
1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26
|
|---|---|
| Published in |
Biomolecular NMR Assignments, February 2016
|
| DOI | 10.1007/s12104-016-9673-z |
| Pubmed ID | |
| Authors |
Riccardo Peruzzini, Zoé Lens, Alexis Verger, Frédérique Dewitte, Elisabeth Ferreira, Jean-Luc Baert, Vincent Villeret, Isabelle Landrieu, François-Xavier Cantrelle |
| Abstract |
MED26 is a subunit of the Mediator, a very large complex involved in regulation of gene transcription by RNA Polymerase II. MED26 regulates the switch between initiation and elongation phases of the transcription. This function requires interaction of its N-terminal domain (NTD) with several protein partners implicated in transcriptional regulation. Molecular details of the structure and interaction mode of MED26 NTD would improve understanding of this complex regulation. As a first step towards structural characterization, sequence specific (1)H, (13)C and (15)N assignments for MED26 NTD was performed based on Nuclear Magnetic Resonance spectroscopy. TALOS+ analysis of the chemical shifts data revealed a domain solely composed of helices. Assignments will be further used to solve NMR structure and dynamics of MED26 NTD and investigate the molecular details of its interaction with protein partners. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 38% |
| Researcher | 2 | 25% |
| Student > Ph. D. Student | 1 | 13% |
| Student > Postgraduate | 1 | 13% |
| Unknown | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 75% |
| Agricultural and Biological Sciences | 1 | 13% |
| Unknown | 1 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2016.
All research outputs
#16,669,623
of 24,525,936 outputs
Outputs from Biomolecular NMR Assignments
#109
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Outputs of similar age
#246,291
of 409,973 outputs
Outputs of similar age from Biomolecular NMR Assignments
#3
of 10 outputs
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