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Attention Score in Context
| Title |
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
|
|---|---|
| Published in |
Nature Genetics, June 2009
|
| DOI | 10.1038/ng.396 |
| Pubmed ID | |
| Authors |
Melanie Bahlo, David R Booth, Simon A Broadley, Matthew A Brown, Simon J Foote, Lyn R Griffiths, Trevor J Kilpatrick, Jeanette Lechner-Scott, Pablo Moscato, Victoria M Perreau, Justin P Rubio, Rodney J Scott, Jim Stankovich, Graeme J Stewart, Bruce V Taylor, James Wiley, Matthew A Brown, David R Booth, Glynnis Clarke, Mathew B Cox, Peter A Csurhes, Patrick Danoy, Karen Drysdale, Judith Field, Simon J Foote, Judith M Greer, Lyn R Griffiths, Preethi Guru, Johanna Hadler, Brendan J McMorran, Cathy J Jensen, Laura J Johnson, Ruth McCallum, Marilyn Merriman, Tony Merriman, Karen Pryce, Rodney J Scott, Graeme J Stewart, Lotfi Tajouri, Ella J Wilkins, Justin P Rubio, Melanie Bahlo, Matthew A Brown, Brian L Browning, Sharon R Browning, Devindri Perera, Justin P Rubio, Jim Stankovich, Simon Broadley, Helmut Butzkueven, William M Carroll, Caron Chapman, Allan G Kermode, Mark Marriott, Deborah Mason, Robert N Heard, Michael P Pender, Mark Slee, Niall Tubridy, Jeanette Lechner-Scott, Bruce V Taylor, Ernest Willoughby, Trevor J Kilpatrick |
| Abstract |
To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 x 10(-11); rs10876994, P = 2.7 x 10(-10); rs12368653, P = 1.0 x 10(-7)) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 x 10(-7); rs1569723, P = 2.9 x 10(-7)). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001). |
Mendeley readers
The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Australia | 2 | <1% |
| Spain | 2 | <1% |
| Cuba | 1 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| New Zealand | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 280 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 58 | 20% |
| Student > Ph. D. Student | 54 | 18% |
| Student > Bachelor | 36 | 12% |
| Student > Master | 22 | 8% |
| Student > Doctoral Student | 17 | 6% |
| Other | 64 | 22% |
| Unknown | 41 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 24% |
| Medicine and Dentistry | 61 | 21% |
| Biochemistry, Genetics and Molecular Biology | 41 | 14% |
| Neuroscience | 15 | 5% |
| Immunology and Microbiology | 15 | 5% |
| Other | 43 | 15% |
| Unknown | 48 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2019.
All research outputs
#6,377,613
of 22,660,862 outputs
Outputs from Nature Genetics
#5,093
of 7,173 outputs
Outputs of similar age
#33,508
of 112,324 outputs
Outputs of similar age from Nature Genetics
#44
of 58 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 7,173 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.9. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,324 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.