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Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age

Overview of attention for article published in GeroScience, April 2015
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Title
Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age
Published in
GeroScience, April 2015
DOI 10.1007/s11357-015-9771-3
Pubmed ID
Authors

Kelly van Drielen, David A. Gunn, Raymond Noordam, Christopher E. M. Griffiths, Rudi G. J. Westendorp, Anton J. M. de Craen, Diana van Heemst

Abstract

Circulatory levels of insulin-like growth factor (IGF-1), glucose, and cortisol have been previously associated with facial aging. However, as these serum measures are related, it is unclear whether their associations with skin aging occur independently from each other. We aimed to investigate whether the associations between serum IGF-1, glucose, and cortisol levels and perceived age/wrinkle grade occur independently of each other and whether these are mediated via skin wrinkling or via other skin aging features. Perceived age and skin wrinkling grade were assessed in a random sample from the Leiden Longevity Study with non-fasted (N = 579) and fasted blood sampling (N = 219). In our study population, a higher non-fasted IGF-1 level was associated with a lower skin wrinkling grade (p value = 0.014) and tended to associate with a lower perceived age (p value = 0.067), which was mediated for approximately 100 % by skin wrinkling. A higher non-fasted glucose level was associated with a higher perceived age (p value = 0.017), which was mediated for 51 % by skin wrinkling grade (p value = 0.112). A higher fasted cortisol level tended to associate with a higher perceived age (p value = 0.116), which was mediated for 29 % by skin wrinkling. Results remained similar when the serum measures were statistically adjusted for each other. Thus, the previously reported serum measures associate independently from each other with skin aging. IGF-1 is predominantly associated with perceived age by skin wrinkling, whereas cortisol and glucose also by other skin aging features.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Professor 3 14%
Other 2 10%
Professor > Associate Professor 2 10%
Student > Master 2 10%
Other 4 19%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 8 38%
Nursing and Health Professions 3 14%
Biochemistry, Genetics and Molecular Biology 1 5%
Earth and Planetary Sciences 1 5%
Agricultural and Biological Sciences 1 5%
Other 2 10%
Unknown 5 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2017.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from GeroScience
#1,512
of 1,594 outputs
Outputs of similar age
#225,582
of 262,382 outputs
Outputs of similar age from GeroScience
#22
of 25 outputs
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