| Title |
Protein Dimerization and Oligomerization in Biology
|
|---|---|
| Chapter number | 7 |
| Published by |
Advances in experimental medicine and biology, January 2012
|
| DOI | 10.1007/978-1-4614-3229-6 |
| Pubmed ID | |
| ISBNs |
978-1-4614-3228-9, 978-1-4614-3229-6
|
| Authors |
Funnell, Alister P W, Crossley, Merlin, Funnell, Alister P. W., Alister P. W. Funnell, Merlin Crossley |
| Editors |
Jacqueline M. Matthews |
| Abstract |
Eukaryotic transcription factors bind DNA and typically serve to localize large multiprotein complexes to particular genes to up- or downregulate transcription, thereby coordinating cellular responses to a variety of signals. Different combinations of transcription factors within DNA-binding multiprotein complexes allow individual proteins to partake in multiple different regulatory pathways. Many transcription factors can form homo- and heterodimers (or oligomers) with different partners, thus modulating DNA-binding specificity and affinity and/or the recruitment of different binding partners. This chapter reviews several of the mechanisms by which the homo- and heterodimerization of transcription factors contributes to transcriptional regulation. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 140 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 9% |
| Researcher | 7 | 5% |
| Student > Bachelor | 6 | 4% |
| Student > Master | 5 | 4% |
| Student > Postgraduate | 3 | 2% |
| Other | 2 | 1% |
| Unknown | 105 | 74% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 13% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Medicine and Dentistry | 4 | 3% |
| Immunology and Microbiology | 1 | <1% |
| Neuroscience | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 105 | 74% |