Title |
An In Vitro Study of the Neurotoxic Effects of N-Benzylpiperazine: A Designer Drug of Abuse
|
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Published in |
Neurotoxicity Research, February 2016
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DOI | 10.1007/s12640-016-9604-x |
Pubmed ID | |
Authors |
Karolina Persona, Anna Polus, Joanna Góralska, Anna Gruca, Aldona Dembińska-Kieć, Wojciech Piekoszewski |
Abstract |
Recently, the number of new psychoactive substances has significantly increased. Despite the systematic introduction of prohibition in trade of medicinal products which mimic the effects of illegal drugs, the problem concerning this group of drugs is still important although knowledge about the mechanism of action of those types of substances is scarce. This study aimed to follow the neurotoxic effect of N-benzylpiperazine (BZP), the central nervous system psychostimulant, using the human cancer LN-18 cell model. The statistically significant elevation of LDH levels, increased mitochondrial membrane potential, decreased ATP and increased ROS production, increased levels of DNA damage marker (8-OHdG) and activation of caspases: -3 and -9 confirmed by Real-Time PCR imply the activation of mitochondrial proapoptotic pathways induced by BZP after 24 h incubation. This study is a novel, preliminary attempt to explain the toxicity of one of the most popular designer drug of abuse at the cellular level. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 25% |
Student > Ph. D. Student | 5 | 16% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 2 | 6% |
Professor | 2 | 6% |
Other | 5 | 16% |
Unknown | 7 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 8 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 19% |
Medicine and Dentistry | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Psychology | 1 | 3% |
Other | 3 | 9% |
Unknown | 8 | 25% |