↓ Skip to main content

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

Overview of attention for article published in Nature Neuroscience, November 2009
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 X user
f1000
1 research highlight platform

Citations

dimensions_citation
657 Dimensions

Readers on

mendeley
847 Mendeley
citeulike
4 CiteULike
connotea
1 Connotea
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Published in
Nature Neuroscience, November 2009
DOI 10.1038/nn.2447
Pubmed ID
Authors

Juan E Belforte, Veronika Zsiros, Elyse R Sklar, Zhihong Jiang, Gu Yu, Yuqing Li, Elizabeth M Quinlan, Kazu Nakazawa

Abstract

Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development. Consistent with the NMDAR hypofunction theory of schizophrenia, distinct schizophrenia-related symptoms emerged after adolescence, including novelty-induced hyperlocomotion, mating and nest-building deficits, as well as anhedonia-like and anxiety-like behaviors. Many of these behaviors were exacerbated by social isolation stress. Social memory, spatial working memory and prepulse inhibition were also impaired. Reduced expression of glutamic acid decarboxylase 67 and parvalbumin was accompanied by disinhibition of cortical excitatory neurons and reduced neuronal synchrony. Postadolescent deletion of NR1 did not result in such abnormalities. These findings suggest that early postnatal inhibition of NMDAR activity in corticolimbic GABAergic interneurons contributes to the pathophysiology of schizophrenia-related disorders.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 847 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 22 3%
United Kingdom 8 <1%
Japan 4 <1%
Germany 3 <1%
Argentina 3 <1%
Brazil 2 <1%
Australia 2 <1%
Netherlands 2 <1%
Spain 2 <1%
Other 19 2%
Unknown 780 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 183 22%
Researcher 170 20%
Student > Bachelor 114 13%
Student > Master 85 10%
Professor 41 5%
Other 137 16%
Unknown 117 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 290 34%
Neuroscience 187 22%
Medicine and Dentistry 101 12%
Psychology 59 7%
Biochemistry, Genetics and Molecular Biology 30 4%
Other 41 5%
Unknown 139 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2013.
All research outputs
#15,367,724
of 24,363,506 outputs
Outputs from Nature Neuroscience
#4,687
of 5,437 outputs
Outputs of similar age
#79,156
of 96,242 outputs
Outputs of similar age from Nature Neuroscience
#35
of 53 outputs
Altmetric has tracked 24,363,506 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,437 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,242 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.