Title |
Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
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Published in |
Annals of Oncology, February 2010
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DOI | 10.1093/annonc/mdq027 |
Pubmed ID | |
Authors |
F Morschhauser, P Marlton, U Vitolo, O Lindén, J F Seymour, M Crump, B Coiffier, R Foà, E Wassner, H-U Burger, B Brennan, M Mendila |
Abstract |
Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3 weeks: cohort A, 200 mg/m(2) (n = 15); cohort B, 375 mg/m(2) (n = 16); cohort C, first dose 375 mg/m(2), seven subsequent doses of 750 mg/m(2) (n = 16). Patients were assessed for safety, efficacy, pharmacodynamics and pharmacokinetics. |
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Demographic breakdown
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Student > Ph. D. Student | 11 | 14% |
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