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Mendeley readers
Attention Score in Context
| Title |
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, October 2007
|
| DOI | 10.1073/pnas.0702275104 |
| Pubmed ID | |
| Authors |
Yanling Zhang, Sergey N. Zolov, Clement Y. Chow, Shalom G. Slutsky, Simon C. Richardson, Robert C. Piper, Baoli Yang, Johnathan J. Nau, Randal J. Westrick, Sean J. Morrison, Miriam H. Meisler, Lois S. Weisman |
| Abstract |
The signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)), likely functions in multiple signaling pathways. Here, we report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P(2) synthesis. The mutant mice exhibit massive neurodegeneration, particularly in the midbrain and in peripheral sensory neurons. Cell bodies of affected neurons are vacuolated, and apparently empty spaces are present in areas where neurons should be present. Similar vacuoles are found in cultured neurons and fibroblasts. Selective membrane trafficking pathways, especially endosome-to-TGN retrograde trafficking, are defective. This report, along with a recent report on a mouse with a null mutation in Fig4, presents the unexpected finding that the housekeeping lipid, PI(3,5)P(2), is critical for the survival of neural cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Gambia | 1 | <1% |
| Portugal | 1 | <1% |
| Greece | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 131 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 23% |
| Researcher | 23 | 17% |
| Student > Bachelor | 10 | 7% |
| Student > Master | 10 | 7% |
| Student > Doctoral Student | 8 | 6% |
| Other | 19 | 14% |
| Unknown | 35 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 31% |
| Biochemistry, Genetics and Molecular Biology | 32 | 23% |
| Neuroscience | 7 | 5% |
| Medicine and Dentistry | 7 | 5% |
| Linguistics | 2 | 1% |
| Other | 7 | 5% |
| Unknown | 39 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2024.
All research outputs
#3,273,093
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#34,483
of 101,438 outputs
Outputs of similar age
#8,273
of 80,277 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#192
of 613 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 80,277 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 613 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.