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Mendeley readers
Attention Score in Context
| Title |
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
|
|---|---|
| Published in |
Nature Neuroscience, February 2008
|
| DOI | 10.1038/nn2055 |
| Pubmed ID | |
| Authors |
Alexis M Stranahan, Thiruma V Arumugam, Roy G Cutler, Kim Lee, Josephine M Egan, Mark P Mattson |
| Abstract |
Many organ systems are adversely affected by diabetes, including the brain, which undergoes changes that may increase the risk of cognitive decline. Although diabetes influences the hypothalamic-pituitary-adrenal axis, the role of this neuroendocrine system in diabetes-induced cognitive dysfunction remains unexplored. Here we demonstrate that, in both insulin-deficient rats and insulin-resistant mice, diabetes impairs hippocampus-dependent memory, perforant path synaptic plasticity and adult neurogenesis, and the adrenal steroid corticosterone contributes to these adverse effects. Rats treated with streptozocin have reduced insulin and show hyperglycemia, increased corticosterone, and impairments in hippocampal neurogenesis, synaptic plasticity and learning. Similar deficits are observed in db/db mice, which are characterized by insulin resistance, elevated corticosterone and obesity. Changes in hippocampal plasticity and function in both models are reversed when normal physiological levels of corticosterone are maintained, suggesting that cognitive impairment in diabetes may result from glucocorticoid-mediated deficits in neurogenesis and synaptic plasticity. |
Mendeley readers
The data shown below were compiled from readership statistics for 345 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 2 | <1% |
| Netherlands | 1 | <1% |
| Austria | 1 | <1% |
| Brazil | 1 | <1% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 332 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 75 | 22% |
| Researcher | 69 | 20% |
| Student > Master | 43 | 12% |
| Student > Bachelor | 27 | 8% |
| Professor | 25 | 7% |
| Other | 65 | 19% |
| Unknown | 41 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 89 | 26% |
| Neuroscience | 62 | 18% |
| Medicine and Dentistry | 59 | 17% |
| Psychology | 22 | 6% |
| Biochemistry, Genetics and Molecular Biology | 17 | 5% |
| Other | 30 | 9% |
| Unknown | 66 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2021.
All research outputs
#4,144,328
of 22,660,862 outputs
Outputs from Nature Neuroscience
#3,075
of 5,206 outputs
Outputs of similar age
#13,897
of 79,058 outputs
Outputs of similar age from Nature Neuroscience
#16
of 47 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,206 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 52.9. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 79,058 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.