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Mendeley readers
Attention Score in Context
| Title |
Drosophila melanogaster Mounts a Unique Immune Response to the Rhabdovirus Sigma virus▿
|
|---|---|
| Published in |
Applied and Environmental Microbiology, March 2008
|
| DOI | 10.1128/aem.02248-07 |
| Pubmed ID | |
| Authors |
C. W. Tsai, E. A. McGraw, E.-D. Ammar, R. G. Dietzgen, S. A. Hogenhout |
| Abstract |
Rhabdoviruses are important pathogens of humans, livestock, and plants that are often vectored by insects. Rhabdovirus particles have a characteristic bullet shape with a lipid envelope and surface-exposed transmembrane glycoproteins. Sigma virus (SIGMAV) is a member of the Rhabdoviridae and is a naturally occurring disease agent of Drosophila melanogaster. The infection is maintained in Drosophila populations through vertical transmission via germ cells. We report here the nature of the Drosophila innate immune response to SIGMAV infection as revealed by quantitative reverse transcription-PCR analysis of differentially expressed genes identified by microarray analysis. We have also compared and contrasted the immune response of the host with respect to two nonenveloped viruses, Drosophila C virus (DCV) and Drosophila X virus (DXV). We determined that SIGMAV infection upregulates expression of the peptidoglycan receptor protein genes PGRP-SB1 and PGRP-SD and the antimicrobial peptide (AMP) genes Diptericin-A, Attacin-A, Attacin-B, Cecropin-A1, and Drosocin. SIGMAV infection did not induce PGRP-SA and the AMP genes Drosomycin-B, Metchnikowin, and Defensin that are upregulated in DCV and/or DXV infections. Expression levels of the Toll and Imd signaling cascade genes are not significantly altered by SIGMAV infection. These results highlight shared and unique aspects of the Drosophila immune response to the three viruses and may shed light on the nature of the interaction with the host and the evolution of these associations. |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Finland | 1 | 1% |
| Netherlands | 1 | 1% |
| Egypt | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 75 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 31% |
| Researcher | 18 | 22% |
| Student > Master | 15 | 18% |
| Student > Bachelor | 8 | 10% |
| Professor > Associate Professor | 7 | 8% |
| Other | 2 | 2% |
| Unknown | 7 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 63% |
| Biochemistry, Genetics and Molecular Biology | 15 | 18% |
| Immunology and Microbiology | 3 | 4% |
| Environmental Science | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 7 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2015.
All research outputs
#7,355,485
of 25,371,288 outputs
Outputs from Applied and Environmental Microbiology
#7,416
of 19,160 outputs
Outputs of similar age
#30,062
of 96,085 outputs
Outputs of similar age from Applied and Environmental Microbiology
#62
of 118 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 19,160 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,085 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.