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Mendeley readers
Attention Score in Context
| Title |
A phosphatase cascade by which rewarding stimuli control nucleosomal response
|
|---|---|
| Published in |
Nature, May 2008
|
| DOI | 10.1038/nature06994 |
| Pubmed ID | |
| Authors |
Alexandre Stipanovich, Emmanuel Valjent, Miriam Matamales, Akinori Nishi, Jung-Hyuck Ahn, Matthieu Maroteaux, Jesus Bertran-Gonzalez, Karen Brami-Cherrier, Hervé Enslen, Anne-Gaëlle Corbillé, Odile Filhol, Angus C. Nairn, Paul Greengard, Denis Hervé, Jean-Antoine Girault |
| Abstract |
Dopamine orchestrates motor behaviour and reward-driven learning. Perturbations of dopamine signalling have been implicated in several neurological and psychiatric disorders, and in drug addiction. The actions of dopamine are mediated in part by the regulation of gene expression in the striatum, through mechanisms that are not fully understood. Here we show that drugs of abuse, as well as food reinforcement learning, promote the nuclear accumulation of 32-kDa dopamine-regulated and cyclic-AMP-regulated phosphoprotein (DARPP-32). This accumulation is mediated through a signalling cascade involving dopamine D1 receptors, cAMP-dependent activation of protein phosphatase-2A, dephosphorylation of DARPP-32 at Ser 97 and inhibition of its nuclear export. The nuclear accumulation of DARPP-32, a potent inhibitor of protein phosphatase-1, increases the phosphorylation of histone H3, an important component of nucleosomal response. Mutation of Ser 97 profoundly alters behavioural effects of drugs of abuse and decreases motivation for food, underlining the functional importance of this signalling cascade. |
Mendeley readers
The data shown below were compiled from readership statistics for 209 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 3% |
| United Kingdom | 3 | 1% |
| Japan | 2 | <1% |
| France | 2 | <1% |
| Australia | 2 | <1% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Singapore | 1 | <1% |
| Pakistan | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 188 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 58 | 28% |
| Student > Ph. D. Student | 42 | 20% |
| Professor > Associate Professor | 21 | 10% |
| Professor | 15 | 7% |
| Student > Bachelor | 12 | 6% |
| Other | 40 | 19% |
| Unknown | 21 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 84 | 40% |
| Neuroscience | 35 | 17% |
| Medicine and Dentistry | 17 | 8% |
| Psychology | 15 | 7% |
| Biochemistry, Genetics and Molecular Biology | 14 | 7% |
| Other | 16 | 8% |
| Unknown | 28 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2008.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from Nature
#84,227
of 90,600 outputs
Outputs of similar age
#69,569
of 82,227 outputs
Outputs of similar age from Nature
#565
of 635 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 90,600 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.2. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,227 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 635 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.