Title |
The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in Drosophila
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Published in |
BMC Molecular and Cell Biology, July 2008
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DOI | 10.1186/1471-2121-9-38 |
Pubmed ID | |
Authors |
Monique Laval, Christophe Bel, Catherine Faivre-Sarrailh |
Abstract |
A complex of three cell adhesion molecules (CAMs) Neurexin IV(Nrx IV), Contactin (Cont) and Neuroglian (Nrg) is implicated in the formation of septate junctions between epithelial cells in Drosophila. These CAMs are interdependent for their localization at septate junctions and e.g. null mutation of nrx IV or cont induces the mislocalization of Nrg to the baso-lateral membrane. These mutations also result in ultrastructural alteration of the strands of septate junctions and breakdown of the paracellular barrier. Varicose (Vari) and Coracle (Cora), that both interact with the cytoplasmic tail of Nrx IV, are scaffolding molecules required for the formation of septate junctions. |
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