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Mendeley readers
Attention Score in Context
| Title |
E2A Proteins Promote Development of Lymphoid-Primed Multipotent Progenitors
|
|---|---|
| Published in |
Immunity, July 2008
|
| DOI | 10.1016/j.immuni.2008.05.015 |
| Pubmed ID | |
| Authors |
Sheila Dias, Robert Månsson, Sandeep Gurbuxani, Mikael Sigvardsson, Barbara L. Kee |
| Abstract |
The first lymphoid-restricted progeny of hematopoietic stem cells (HSCs) are lymphoid-primed multipotent progenitors (LMPPs), which have little erythromyeloid potential but retain lymphoid, granulocyte, and macrophage differentiation capacity. Despite recent advances in the identification of LMPPs, the transcription factors essential for their generation remain to be identified. Here, we demonstrated that the E2A transcription factors were required for proper development of LMPPs. Within HSCs and LMPPs, E2A proteins primed expression of a subset of lymphoid-associated genes and prevented expression of genes that are not normally prevalent in these cells, including HSC-associated and nonlymphoid genes. E2A proteins also restricted proliferation of HSCs, MPPs, and LMPPs and antagonized differentiation of LMPPs toward the myeloid fate. Our results reveal that E2A proteins play a critical role in supporting lymphoid specification from HSCs and that the reduced generation of LMPPs underlies the severe lymphocyte deficiencies observed in E2A-deficient mice. |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 111 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 31% |
| Researcher | 32 | 27% |
| Student > Doctoral Student | 12 | 10% |
| Student > Bachelor | 10 | 8% |
| Student > Master | 10 | 8% |
| Other | 13 | 11% |
| Unknown | 5 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 40% |
| Biochemistry, Genetics and Molecular Biology | 29 | 25% |
| Immunology and Microbiology | 16 | 14% |
| Medicine and Dentistry | 14 | 12% |
| Engineering | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 4 | 3% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2015.
All research outputs
#7,356,343
of 25,374,647 outputs
Outputs from Immunity
#3,299
of 4,816 outputs
Outputs of similar age
#30,795
of 97,615 outputs
Outputs of similar age from Immunity
#23
of 36 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,816 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,615 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.