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Mendeley readers
Attention Score in Context
| Title |
HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
|
|---|---|
| Published in |
Science, January 2009
|
| DOI | 10.1126/science.1169841 |
| Pubmed ID | |
| Authors |
Tara L. Roberts, Adi Idris, Jasmyn A. Dunn, Greg M. Kelly, Carol M. Burnton, Samantha Hodgson, Lani L. Hardy, Valerie Garceau, Matthew J. Sweet, Ian L. Ross, David A. Hume, Katryn J. Stacey |
| Abstract |
The mammalian innate immune system is activated by foreign nucleic acids. Detection of double-stranded DNA (dsDNA) in the cytoplasm triggers characteristic antiviral responses and macrophage cell death. Cytoplasmic dsDNA rapidly activated caspase 3 and caspase 1 in bone marrow-derived macrophages. We identified the HIN-200 family member and candidate lupus susceptibility factor, p202, as a dsDNA binding protein that bound stably and rapidly to transfected DNA. Knockdown studies showed p202 to be an inhibitor of DNA-induced caspase activation. Conversely, the related pyrin domain-containing HIN-200 factor, AIM2 (p210), was required for caspase activation by cytoplasmic dsDNA. This work indicates that HIN-200 proteins can act as pattern recognition receptors mediating responses to cytoplasmic dsDNA. |
Mendeley readers
The data shown below were compiled from readership statistics for 285 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 6 | 2% |
| United States | 6 | 2% |
| United Kingdom | 4 | 1% |
| Netherlands | 2 | <1% |
| France | 2 | <1% |
| Australia | 2 | <1% |
| Brazil | 1 | <1% |
| Hungary | 1 | <1% |
| Colombia | 1 | <1% |
| Other | 4 | 1% |
| Unknown | 256 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 81 | 28% |
| Researcher | 57 | 20% |
| Student > Bachelor | 24 | 8% |
| Student > Master | 23 | 8% |
| Professor > Associate Professor | 16 | 6% |
| Other | 43 | 15% |
| Unknown | 41 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 36% |
| Biochemistry, Genetics and Molecular Biology | 43 | 15% |
| Immunology and Microbiology | 42 | 15% |
| Medicine and Dentistry | 31 | 11% |
| Chemistry | 3 | 1% |
| Other | 13 | 5% |
| Unknown | 51 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2021.
All research outputs
#4,835,157
of 25,371,288 outputs
Outputs from Science
#41,195
of 82,910 outputs
Outputs of similar age
#25,562
of 183,208 outputs
Outputs of similar age from Science
#207
of 360 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,910 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,208 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 360 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.