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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Overview of attention for article published in Nature Immunology, January 2009
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
1 blog
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12 patents
wikipedia
4 Wikipedia pages
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1 research highlight platform

Citations

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897 Dimensions

Readers on

mendeley
453 Mendeley
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1 Connotea
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Title
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
Published in
Nature Immunology, January 2009
DOI 10.1038/ni.1702
Pubmed ID
Authors

Tilmann Bürckstümmer, Christoph Baumann, Stephan Blüml, Evelyn Dixit, Gerhard Dürnberger, Hannah Jahn, Melanie Planyavsky, Martin Bilban, Jacques Colinge, Keiryn L Bennett, Giulio Superti-Furga

Abstract

Cytoplasmic DNA triggers activation of the innate immune system. Although 'downstream' signaling components have been characterized, the DNA-sensing components remain elusive. Here we present a systematic proteomics screen for proteins that associate with DNA, 'crossed' to a screen for transcripts induced by interferon-beta, which identified AIM2 as a candidate cytoplasmic DNA sensor. AIM2 showed specificity for double-stranded DNA. It also recruited the inflammasome adaptor ASC and localized to ASC 'speckles'. A decrease in AIM2 expression produced by RNA-mediated interference impaired DNA-induced maturation of interleukin 1beta in THP-1 human monocytic cells, which indicated that endogenous AIM2 is required for DNA recognition. Reconstitution of unresponsive HEK293 cells with AIM2, ASC, caspase-1 and interleukin 1beta showed that AIM2 was sufficient for inflammasome activation. Our data suggest that AIM2 is a cytoplasmic DNA sensor for the inflammasome.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 453 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 6 1%
United States 5 1%
France 4 <1%
Netherlands 3 <1%
Austria 2 <1%
United Kingdom 2 <1%
China 2 <1%
Australia 1 <1%
Canada 1 <1%
Other 4 <1%
Unknown 423 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 126 28%
Researcher 81 18%
Student > Bachelor 46 10%
Student > Master 41 9%
Professor > Associate Professor 22 5%
Other 68 15%
Unknown 69 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 170 38%
Biochemistry, Genetics and Molecular Biology 68 15%
Immunology and Microbiology 64 14%
Medicine and Dentistry 42 9%
Neuroscience 9 2%
Other 25 6%
Unknown 75 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2024.
All research outputs
#1,654,962
of 23,164,913 outputs
Outputs from Nature Immunology
#947
of 3,839 outputs
Outputs of similar age
#7,214
of 171,920 outputs
Outputs of similar age from Nature Immunology
#2
of 30 outputs
Altmetric has tracked 23,164,913 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,839 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,920 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.