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Mendeley readers
Attention Score in Context
| Title |
Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction
|
|---|---|
| Published in |
Hypertension, December 2009
|
| DOI | 10.1161/hypertensionaha.109.145094 |
| Pubmed ID | |
| Authors |
Meena S. Madhur, Heinrich E. Lob, Louise A. McCann, Yoichiro Iwakura, Yelena Blinder, Tomasz J. Guzik, David G. Harrison |
| Abstract |
We have shown previously that T cells are required for the full development of angiotensin II-induced hypertension. However, the specific subsets of T cells that are important in this process are unknown. T helper 17 cells represent a novel subset that produces the proinflammatory cytokine interleukin 17 (IL-17). We found that angiotensin II infusion increased IL-17 production from T cells and IL-17 protein in the aortic media. To determine the effect of IL-17 on blood pressure and vascular function, we studied IL-17(-/-) mice. The initial hypertensive response to angiotensin II infusion was similar in IL-17(-/-) and C57BL/6J mice. However, hypertension was not sustained in IL-17(-/-) mice, reaching levels 30-mm Hg lower than in wild-type mice by 4 weeks of angiotensin II infusion. Vessels from IL-17(-/-) mice displayed preserved vascular function, decreased superoxide production, and reduced T-cell infiltration in response to angiotensin II. Gene array analysis of cultured human aortic smooth muscle cells revealed that IL-17, in conjunction with tumor necrosis factor-alpha, modulated expression of >30 genes, including a number of inflammatory cytokines/chemokines. Examination of IL-17 in diabetic humans showed that serum levels of this cytokine were significantly increased in those with hypertension compared with normotensive subjects. We conclude that IL-17 is critical for the maintenance of angiotensin II-induced hypertension and vascular dysfunction and might be a therapeutic target for this widespread disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 321 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| Netherlands | 1 | <1% |
| Colombia | 1 | <1% |
| Canada | 1 | <1% |
| Chile | 1 | <1% |
| Unknown | 313 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 17% |
| Researcher | 53 | 17% |
| Student > Bachelor | 36 | 11% |
| Student > Master | 33 | 10% |
| Student > Doctoral Student | 23 | 7% |
| Other | 59 | 18% |
| Unknown | 62 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 105 | 33% |
| Agricultural and Biological Sciences | 49 | 15% |
| Biochemistry, Genetics and Molecular Biology | 29 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 6% |
| Immunology and Microbiology | 13 | 4% |
| Other | 28 | 9% |
| Unknown | 79 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2023.
All research outputs
#2,863,957
of 25,374,647 outputs
Outputs from Hypertension
#1,289
of 7,138 outputs
Outputs of similar age
#13,789
of 172,262 outputs
Outputs of similar age from Hypertension
#4
of 42 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,138 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,262 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.