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Mendeley readers
Attention Score in Context
| Title |
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
|
|---|---|
| Published in |
Nature Immunology, June 2010
|
| DOI | 10.1038/ni.1891 |
| Pubmed ID | |
| Authors |
Yin C Lin, Suchit Jhunjhunwala, Christopher Benner, Sven Heinz, Eva Welinder, Robert Mansson, Mikael Sigvardsson, James Hagman, Celso A Espinoza, Janusz Dutkowski, Trey Ideker, Christopher K Glass, Cornelis Murre |
| Abstract |
It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate. |
Mendeley readers
The data shown below were compiled from readership statistics for 405 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 1% |
| Germany | 2 | <1% |
| Netherlands | 2 | <1% |
| France | 2 | <1% |
| Czechia | 2 | <1% |
| Japan | 2 | <1% |
| Brazil | 1 | <1% |
| China | 1 | <1% |
| Sweden | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 384 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 122 | 30% |
| Researcher | 92 | 23% |
| Student > Master | 30 | 7% |
| Professor > Associate Professor | 26 | 6% |
| Student > Doctoral Student | 25 | 6% |
| Other | 73 | 18% |
| Unknown | 37 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 196 | 48% |
| Biochemistry, Genetics and Molecular Biology | 80 | 20% |
| Medicine and Dentistry | 31 | 8% |
| Immunology and Microbiology | 29 | 7% |
| Computer Science | 8 | 2% |
| Other | 19 | 5% |
| Unknown | 42 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2012.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from Nature Immunology
#3,168
of 3,775 outputs
Outputs of similar age
#77,464
of 95,722 outputs
Outputs of similar age from Nature Immunology
#30
of 34 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,775 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.9. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,722 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.