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Magnetoencephalography Demonstrates Multiple Asynchronous Generators During Human Sleep Spindles

Overview of attention for article published in Journal of Neurophysiology, April 2010
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Title
Magnetoencephalography Demonstrates Multiple Asynchronous Generators During Human Sleep Spindles
Published in
Journal of Neurophysiology, April 2010
DOI 10.1152/jn.00198.2010
Pubmed ID
Authors

Nima Dehghani, Sydney S. Cash, Andrea O. Rossetti, Chih Chuan Chen, Eric Halgren

Abstract

Sleep spindles are approximately 1 s bursts of 10-16 Hz activity that occur during stage 2 sleep. Spindles are highly synchronous across the cortex and thalamus in animals, and across the scalp in humans, implying correspondingly widespread and synchronized cortical generators. However, prior studies have noted occasional dissociations of the magnetoencephalogram (MEG) from the EEG during spindles, although detailed studies of this phenomenon have been lacking. We systematically compared high-density MEG and EEG recordings during naturally occurring spindles in healthy humans. As expected, EEG was highly coherent across the scalp, with consistent topography across spindles. In contrast, the simultaneously recorded MEG was not synchronous, but varied strongly in amplitude and phase across locations and spindles. Overall, average coherence between pairs of EEG sensors was approximately 0.7, whereas MEG coherence was approximately 0.3 during spindles. Whereas 2 principle components explained approximately 50% of EEG spindle variance, >15 were required for MEG. Each PCA component for MEG typically involved several widely distributed locations, which were relatively coherent with each other. These results show that, in contrast to current models based on animal experiments, multiple asynchronous neural generators are active during normal human sleep spindles and are visible to MEG. It is possible that these multiple sources may overlap sufficiently in different EEG sensors to appear synchronous. Alternatively, EEG recordings may reflect diffusely distributed synchronous generators that are less visible to MEG. An intriguing possibility is that MEG preferentially records from the focal core thalamocortical system during spindles, and EEG from the distributed matrix system.

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Mendeley readers

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Geographical breakdown

Country Count As %
United States 2 2%
Canada 2 2%
Korea, Republic of 1 1%
France 1 1%
Unknown 77 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 23%
Student > Ph. D. Student 14 17%
Student > Bachelor 7 8%
Other 7 8%
Professor 6 7%
Other 16 19%
Unknown 14 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 28%
Neuroscience 17 20%
Medicine and Dentistry 13 16%
Psychology 6 7%
Computer Science 3 4%
Other 5 6%
Unknown 16 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2016.
All research outputs
#16,048,009
of 25,374,647 outputs
Outputs from Journal of Neurophysiology
#4,751
of 8,423 outputs
Outputs of similar age
#84,643
of 104,891 outputs
Outputs of similar age from Journal of Neurophysiology
#37
of 51 outputs
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