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MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

Overview of attention for article published in Molecular Cell, September 2010
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  • Average Attention Score compared to outputs of the same age and source

Citations

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372 Mendeley
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Title
MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases
Published in
Molecular Cell, September 2010
DOI 10.1016/j.molcel.2010.08.029
Pubmed ID
Authors

Jennifer M. Doyle, Jinlan Gao, Jiawei Wang, Maojun Yang, Patrick Ryan Potts

Abstract

The melanoma antigen (MAGE) family consists of more than 60 genes, many of which are cancer-testis antigens that are highly expressed in cancer and play a critical role in tumorigenesis. However, the biochemical and cellular functions of this enigmatic family of proteins have remained elusive. Here, we identify really interesting new gene (RING) domain proteins as binding partners for MAGE family proteins. Multiple MAGE family proteins bind E3 RING ubiquitin ligases with specificity. The crystal structure of one of these MAGE-RING complexes, MAGE-G1-NSE1, reveals structural insights into MAGE family proteins and their interaction with E3 RING ubiquitin ligases. Biochemical and cellular assays demonstrate that MAGE proteins enhance the ubiquitin ligase activity of RING domain proteins. For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 372 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
United States 1 <1%
Italy 1 <1%
Canada 1 <1%
Unknown 367 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 86 23%
Researcher 57 15%
Student > Master 47 13%
Student > Bachelor 44 12%
Professor 16 4%
Other 54 15%
Unknown 68 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 133 36%
Biochemistry, Genetics and Molecular Biology 110 30%
Medicine and Dentistry 23 6%
Chemistry 9 2%
Immunology and Microbiology 8 2%
Other 13 3%
Unknown 76 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2017.
All research outputs
#7,356,343
of 25,374,647 outputs
Outputs from Molecular Cell
#4,811
of 7,617 outputs
Outputs of similar age
#33,696
of 103,828 outputs
Outputs of similar age from Molecular Cell
#30
of 54 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.