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Attention Score in Context
| Title |
Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, December 2010
|
| DOI | 10.1073/pnas.0914906108 |
| Pubmed ID | |
| Authors |
Shu-Hong Hu, Michelle P. Christie, Natalie J. Saez, Catherine F. Latham, Russell Jarrott, Linda H. L. Lua, Brett M. Collins, Jennifer L. Martin |
| Abstract |
Munc18-1 and Syntaxin1 are essential proteins for SNARE-mediated neurotransmission. Munc18-1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding closed Syntaxin1, and as a fusion protein that binds SNARE complexes in a Syntaxin1 N-peptide dependent manner. The two roles are associated with a closed-open Syntaxin1 conformational transition. Here, we show that Syntaxin N-peptide binding to Munc18-1 is not highly selective, suggesting that other parts of the SNARE complex are involved in binding to Munc18-1. We also find that Syntaxin1, with an N peptide and a physically anchored C terminus, binds to Munc18-1 and that this complex can participate in SNARE complex formation. We report a Munc18-1-N-peptide crystal structure that, together with other data, reveals how Munc18-1 might transit from a conformation that binds closed Syntaxin1 to one that may be compatible with binding open Syntaxin1 and SNARE complexes. Our results suggest the possibility that structural transitions occur in both Munc18-1 and Syntaxin1 during their binary interaction. We hypothesize that Munc18-1 domain 3a undergoes a conformational change that may allow coiled-coil interactions with SNARE complexes. |
Mendeley readers
The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 198 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 12% |
| Researcher | 18 | 9% |
| Student > Bachelor | 8 | 4% |
| Professor | 5 | 3% |
| Student > Master | 5 | 3% |
| Other | 9 | 5% |
| Unknown | 131 | 66% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 15% |
| Biochemistry, Genetics and Molecular Biology | 21 | 11% |
| Neuroscience | 6 | 3% |
| Medicine and Dentistry | 5 | 3% |
| Chemistry | 3 | 2% |
| Other | 2 | 1% |
| Unknown | 133 | 67% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2016.
All research outputs
#7,080,750
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#59,831
of 101,438 outputs
Outputs of similar age
#49,255
of 190,268 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#423
of 714 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,268 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 714 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.