| Title |
Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, December 2010
|
| DOI | 10.1007/s00018-010-0603-4 |
| Pubmed ID | |
| Authors |
Jacqueline S. Domire, Jill A. Green, Kirsten G. Lee, Andrew D. Johnson, Candice C. Askwith, Kirk Mykytyn |
| Abstract |
Primary cilia are nearly ubiquitous cellular appendages that provide important sensory and signaling functions. Ciliary dysfunction underlies numerous human diseases, collectively termed ciliopathies. Primary cilia have distinct functions on different cell types and these functions are defined by the signaling proteins that localize to the ciliary membrane. Neurons throughout the mammalian brain possess primary cilia upon which certain G protein-coupled receptors localize. Yet, the precise signaling proteins present on the vast majority of neuronal cilia are unknown. Here, we report that dopamine receptor 1 (D1) localizes to cilia on mouse central neurons, thereby implicating neuronal cilia in dopamine signaling. Interestingly, ciliary localization of D1 is dynamic, and the receptor rapidly translocates to and from cilia in response to environmental cues. Notably, the translocation of D1 from cilia requires proteins mutated in the ciliopathy Bardet-Biedl syndrome (BBS), and we find that one of the BBS proteins, Bbs5, specifically interacts with D1. |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Portugal | 1 | <1% |
| Unknown | 107 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 25% |
| Researcher | 25 | 23% |
| Student > Master | 9 | 8% |
| Professor | 9 | 8% |
| Student > Bachelor | 9 | 8% |
| Other | 17 | 15% |
| Unknown | 13 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 41% |
| Biochemistry, Genetics and Molecular Biology | 26 | 24% |
| Neuroscience | 12 | 11% |
| Medicine and Dentistry | 3 | 3% |
| Environmental Science | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 16 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2010.
All research outputs
#16,031,680
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,071
of 4,151 outputs
Outputs of similar age
#145,165
of 185,109 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#20
of 25 outputs
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