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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

Overview of attention for article published in Nature Genetics, October 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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15 patents
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1 research highlight platform

Citations

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515 Dimensions

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342 Mendeley
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1 Connotea
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Title
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Published in
Nature Genetics, October 2008
DOI 10.1038/ng.221
Pubmed ID
Authors

Andre Franke, Tobias Balschun, Tom H Karlsen, Jurgita Sventoraityte, Susanna Nikolaus, Gabriele Mayr, Francisco S Domingues, Mario Albrecht, Michael Nothnagel, David Ellinghaus, Christian Sina, Clive M Onnie, Rinse K Weersma, Pieter C F Stokkers, Cisca Wijmenga, Maria Gazouli, David Strachan, Wendy L McArdle, Séverine Vermeire, Paul Rutgeerts, Philip Rosenstiel, Michael Krawczak, Morten H Vatn, Christopher G Mathew, Stefan Schreiber

Abstract

Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far focused mainly on CD, and little is known about the genetic architecture of UC. Here we report a genome-wide association study with 440,794 SNPs genotyped in 1,167 individuals with UC and 777 healthy controls. Twenty of the most significantly associated SNPs were tested for replication in three independent European case-control panels comprising a total of 1,855 individuals with UC and 3,091 controls. Among the four consistently replicated markers, SNP rs3024505 immediately flanking the IL10 (interleukin 10) gene on chromosome 1q32.1 showed the most significant association in the combined verification samples (P = 1.35 x 10(-12); OR = 1.46 (1.31-1.62)). The other markers were located in ARPC2 and in the HLA-BTNL2 region. Association between rs3024505 and CD (1,848 cases, 1,804 controls) was weak (P = 0.013; OR = 1.17 (1.01-1.34)). IL10 is an immunosuppressive cytokine that has long been proposed to influence IBD pathophysiology. Our findings strongly suggest that defective IL10 function is central to the pathogenesis of the UC subtype of IBD.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 342 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 7 2%
Germany 4 1%
United States 4 1%
Netherlands 2 <1%
Austria 1 <1%
Australia 1 <1%
Iceland 1 <1%
Ireland 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 319 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 87 25%
Student > Ph. D. Student 77 23%
Student > Master 41 12%
Student > Doctoral Student 18 5%
Student > Bachelor 16 5%
Other 54 16%
Unknown 49 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 110 32%
Medicine and Dentistry 68 20%
Biochemistry, Genetics and Molecular Biology 46 13%
Immunology and Microbiology 35 10%
Pharmacology, Toxicology and Pharmaceutical Science 8 2%
Other 17 5%
Unknown 58 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2023.
All research outputs
#3,111,270
of 23,267,128 outputs
Outputs from Nature Genetics
#3,291
of 7,250 outputs
Outputs of similar age
#9,355
of 90,553 outputs
Outputs of similar age from Nature Genetics
#23
of 60 outputs
Altmetric has tracked 23,267,128 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,250 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.5. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,553 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.