| Title |
Determinants of prevalent vertebral fractures and progressive bone loss in long-term hemodialysis patients
|
|---|---|
| Published in |
Journal of Bone and Mineral Metabolism, January 2009
|
| DOI | 10.1007/s00774-008-0030-x |
| Pubmed ID | |
| Authors |
Jan Mares, Kristina Ohlidalova, Sylvie Opatrna, Jiri Ferda |
| Abstract |
Skeletal fractures are common in hemodialysis (HD) patients. However, consensus regarding technique and site of bone examination has not been reached in HD patients. Seventy-two patients (44% females) aged 65 (1.4) years, treated with HD for 43 (4.6) months were examined with quantitative computed tomography and 53 of them re-examined after 1 year. Bone mineral density (BMD) of lumbar spine was established separately for cortical and trabecular bone, prevalent vertebral fractures were determined. Data are given as mean (standard error). At least one vertebral fracture was discovered in 15 (21%) patients. In a logistic regression model, fractures were best predicted by cortical BMD: OR 0.96 (CI 0.94, 0.99), p < 0.005. With a multiple regression analysis, time on dialysis was found to be independently correlated to cortical BMD (R = 0.35, p < 0.005). On follow-up, a decrease of BMD was detected, which occurred only in the cortical region and was significantly greater in females than in males: -7% (1.7) versus 1.2% (1.9), p < 0.005. A time-dependent loss of vertebral cortical bone occurs in HD patients, especially in females. This decrement may impose an increased risk of fractures on long-term dialysis patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 19% |
| Lecturer > Senior Lecturer | 3 | 14% |
| Student > Ph. D. Student | 3 | 14% |
| Researcher | 3 | 14% |
| Other | 2 | 10% |
| Other | 2 | 10% |
| Unknown | 4 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 52% |
| Agricultural and Biological Sciences | 1 | 5% |
| Nursing and Health Professions | 1 | 5% |
| Sports and Recreations | 1 | 5% |
| Engineering | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 6 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2009.
All research outputs
#16,061,913
of 23,842,189 outputs
Outputs from Journal of Bone and Mineral Metabolism
#367
of 787 outputs
Outputs of similar age
#148,128
of 175,947 outputs
Outputs of similar age from Journal of Bone and Mineral Metabolism
#8
of 9 outputs
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So far Altmetric has tracked 787 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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