| Title |
Monoclonal antibody specific for IDH1 R132H mutation
|
|---|---|
| Published in |
Acta Neuropathologica, October 2009
|
| DOI | 10.1007/s00401-009-0595-z |
| Pubmed ID | |
| Authors |
David Capper, Hanswalter Zentgraf, Jörg Balss, Christian Hartmann, Andreas von Deimling |
| Abstract |
IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. We developed a mouse monoclonal antibody targeting the IDH1 R132H mutation. Here, we show the high specificity and sensitivity of this antibody on Western blots and tissue sections from formalin fixed paraffin embedded tumor specimens. This antibody is highly useful for tumor classification, in detecting single infiltrating tumor cells and for the characterization of the cellular role of mutant IDH1 protein. |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 2 | 1% |
| United States | 1 | <1% |
| India | 1 | <1% |
| Nigeria | 1 | <1% |
| Unknown | 130 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 19% |
| Student > Ph. D. Student | 23 | 17% |
| Student > Master | 15 | 11% |
| Student > Postgraduate | 14 | 10% |
| Student > Bachelor | 12 | 9% |
| Other | 25 | 19% |
| Unknown | 21 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 47 | 35% |
| Biochemistry, Genetics and Molecular Biology | 21 | 16% |
| Agricultural and Biological Sciences | 16 | 12% |
| Neuroscience | 7 | 5% |
| Immunology and Microbiology | 6 | 4% |
| Other | 12 | 9% |
| Unknown | 26 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#2,728,135
of 26,017,215 outputs
Outputs from Acta Neuropathologica
#677
of 2,635 outputs
Outputs of similar age
#9,117
of 110,958 outputs
Outputs of similar age from Acta Neuropathologica
#3
of 10 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,635 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,958 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.