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Aberrant Mucin Glycoprotein Patterns of Chronic Rhinosinusitis Patients with Bacterial Biofilms

Overview of attention for article published in American Journal of Rhinology & Allergy, September 2010
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Citations

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34 Mendeley
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Title
Aberrant Mucin Glycoprotein Patterns of Chronic Rhinosinusitis Patients with Bacterial Biofilms
Published in
American Journal of Rhinology & Allergy, September 2010
DOI 10.2500/ajra.2010.24.3504
Pubmed ID
Authors

Lorwai Tan, Alkis Psaltis, Leonie M. Baker, Mike McGuckin, Karine Rousseau, Peter-John Wormald

Abstract

Increasingly bacterial biofilms have been implicated in chronic rhinosinusitis (CRS), and conventional treatment methods have failed to completely eradicate biofilms. (1) Terminal sialic acids present on sinus mucosal glycoproteins are targets for bacterial adherence and biofilm formation. (2) A subpopulation of CRS patients is more susceptible to biofilm formation due to aberrant terminal sialic residue distribution patterns of glycoproteins on their mucosa. (3) The higher levels of sialyl transferase (ST)6Gal1 gene expression contribute to the overall aberrant glycosylation patterns on the host mucosa that predispose this patient cohort to developing biofilms. (4) Mucin glycoprotein MUC7 that has known bactericidal activity displays an overall reduced terminal sugar profile in biofilm positive CRS patients.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Australia 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 21%
Student > Master 5 15%
Student > Bachelor 4 12%
Other 3 9%
Researcher 3 9%
Other 3 9%
Unknown 9 26%
Readers by discipline Count As %
Medicine and Dentistry 18 53%
Agricultural and Biological Sciences 4 12%
Chemistry 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Unknown 10 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2011.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from American Journal of Rhinology & Allergy
#1,009
of 1,389 outputs
Outputs of similar age
#84,765
of 103,819 outputs
Outputs of similar age from American Journal of Rhinology & Allergy
#3
of 7 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,389 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,819 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.