Title |
Aberrant Mucin Glycoprotein Patterns of Chronic Rhinosinusitis Patients with Bacterial Biofilms
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Published in |
American Journal of Rhinology & Allergy, September 2010
|
DOI | 10.2500/ajra.2010.24.3504 |
Pubmed ID | |
Authors |
Lorwai Tan, Alkis Psaltis, Leonie M. Baker, Mike McGuckin, Karine Rousseau, Peter-John Wormald |
Abstract |
Increasingly bacterial biofilms have been implicated in chronic rhinosinusitis (CRS), and conventional treatment methods have failed to completely eradicate biofilms. (1) Terminal sialic acids present on sinus mucosal glycoproteins are targets for bacterial adherence and biofilm formation. (2) A subpopulation of CRS patients is more susceptible to biofilm formation due to aberrant terminal sialic residue distribution patterns of glycoproteins on their mucosa. (3) The higher levels of sialyl transferase (ST)6Gal1 gene expression contribute to the overall aberrant glycosylation patterns on the host mucosa that predispose this patient cohort to developing biofilms. (4) Mucin glycoprotein MUC7 that has known bactericidal activity displays an overall reduced terminal sugar profile in biofilm positive CRS patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Australia | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 21% |
Student > Master | 5 | 15% |
Student > Bachelor | 4 | 12% |
Other | 3 | 9% |
Researcher | 3 | 9% |
Other | 3 | 9% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 53% |
Agricultural and Biological Sciences | 4 | 12% |
Chemistry | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Unknown | 10 | 29% |