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Mendeley readers
Attention Score in Context
| Title |
A Human snoRNA with MicroRNA-Like Functions
|
|---|---|
| Published in |
Molecular Cell, November 2008
|
| DOI | 10.1016/j.molcel.2008.10.017 |
| Pubmed ID | |
| Authors |
Christine Ender, Azra Krek, Marc R. Friedländer, Michaela Beitzinger, Lasse Weinmann, Wei Chen, Sébastien Pfeffer, Nikolaus Rajewsky, Gunter Meister |
| Abstract |
Small noncoding RNAs function in concert with Argonaute (Ago) proteins to regulate gene expression at the level of transcription, mRNA stability, or translation. Ago proteins bind small RNAs and form the core of silencing complexes. Here, we report the analysis of small RNAs associated with human Ago1 and Ago2 revealed by immunoprecipitation and deep sequencing. Among the reads, we find small RNAs originating from the small nucleolar RNA (snoRNA) ACA45. Moreover, processing of ACA45 requires Dicer activity but is independent of Drosha/DGCR8. Using bioinformatic prediction algorithms and luciferase reporter assays, we uncover the mediator subunit CDC2L6 as one potential mRNA target of ACA45 small RNAs, suggesting a role for ACA45-processing products in posttranscriptional gene silencing. We further identify a number of human snoRNAs with microRNA (miRNA)-like processing signatures. We have, therefore, identified a class of small RNAs in human cells that originate from snoRNAs and can function like miRNAs. |
Mendeley readers
The data shown below were compiled from readership statistics for 629 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 3% |
| United Kingdom | 7 | 1% |
| Germany | 4 | <1% |
| France | 2 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Finland | 1 | <1% |
| Austria | 1 | <1% |
| New Zealand | 1 | <1% |
| Other | 7 | 1% |
| Unknown | 588 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 163 | 26% |
| Researcher | 132 | 21% |
| Student > Master | 72 | 11% |
| Student > Bachelor | 42 | 7% |
| Student > Doctoral Student | 36 | 6% |
| Other | 97 | 15% |
| Unknown | 87 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 290 | 46% |
| Biochemistry, Genetics and Molecular Biology | 158 | 25% |
| Medicine and Dentistry | 36 | 6% |
| Neuroscience | 15 | 2% |
| Computer Science | 8 | 1% |
| Other | 25 | 4% |
| Unknown | 97 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2020.
All research outputs
#2,368,934
of 25,837,817 outputs
Outputs from Molecular Cell
#2,363
of 7,699 outputs
Outputs of similar age
#6,903
of 108,641 outputs
Outputs of similar age from Molecular Cell
#6
of 49 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,699 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,641 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.