| Title |
Characterization of multidrug-resistant Gram-negative bacilli isolated from hospitals effluents: first report of a blaOXA-48-like in Klebsiella oxytoca, Algeria
|
|---|---|
| Published in |
Brazilian Journal of Microbiology, December 2018
|
| DOI | 10.1007/s42770-018-0010-9 |
| Pubmed ID | |
| Authors |
Khadidja Yousfi, Abdelaziz Touati, Brigitte Lefebvre, Philippe Garneau, Soumia Brahmi, Alima Gharout-Sait, Josée Harel, Sadjia Bekal |
| Abstract |
The antibiotic susceptibility profile and antimicrobial resistance determinants were characterized on Gram-negative bacilli (GNB) isolated from Algerian hospital effluents. Among the 94 isolates, Enterobacteriaceae was the predominant family, with Escherichia coli and Klebsiella pneumoniae being the most isolated species. In non-Enterobacteriaceae, Acinetobacter and Aeromonas were the predominant species followed by Pseudomonas, Comamonas, Pasteurella, and Shewanella spp. The majority of the isolates were multidrug-resistant (MDR) and carried different antimicrobial resistance genes including blaCTX-M, blaTEM, blaSHV, blaOXA-48-like, blaOXA-23, blaOXA-51, qnrB, qnrS, tet(A), tet(B), tet(C), dfrA1, aac(3)-IIc (aacC2), aac(6')-1b, sul1, and sul2. The qacEΔ1-sul1 and intI2 signatures of class 1 and class 2 integrons, respectively, were also detected. Microarray hybridization on MDR E. coli revealed additional resistance genes (aadA1 and aph3strA, tet30, mphA, dfrA12, blacmy2, blaROB1, and cmlA1) and classified the tested strains as commensals, thus highlighting the potential role of humans in antibiotic resistance dissemination. This study is the first report of blaOXA-48-like in Klebsiella oxytoca in Algeria and blaOXA-23 in A. baumannii in Algerian hospital effluents. The presence of these bacteria and resistance genes in hospital effluents represents a serious public health concern since they can be disseminated in the environment and can colonize other hosts. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 14% |
| Student > Ph. D. Student | 7 | 14% |
| Researcher | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Student > Postgraduate | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 19 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 18% |
| Agricultural and Biological Sciences | 6 | 12% |
| Immunology and Microbiology | 4 | 8% |
| Medicine and Dentistry | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 21 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2019.
All research outputs
#15,030,198
of 23,122,481 outputs
Outputs from Brazilian Journal of Microbiology
#434
of 1,135 outputs
Outputs of similar age
#249,817
of 435,621 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#4
of 17 outputs
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So far Altmetric has tracked 1,135 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
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