| Title |
Amino acid contacts in proteins adapted to different temperatures: hydrophobic interactions and surface charges play a key role
|
|---|---|
| Published in |
Extremophiles, September 2008
|
| DOI | 10.1007/s00792-008-0192-4 |
| Pubmed ID | |
| Authors |
Gisle Sælensminde, Øyvind Halskau, Inge Jonassen |
| Abstract |
Thermophiles, mesophiles, and psychrophiles have different amino acid frequencies in their proteins, probably because of the way the species adapt to very different temperatures in their environment. In this paper, we analyse how contacts between sidechains vary between homologous proteins from species that are adapted to different temperatures, but displaying relatively high sequence similarity. We investigate whether specific contacts between amino acids sidechains is a key factor in thermostabilisation in proteins. The dataset was divided into two subsets with optimal growth temperatures from 0-40 and 35-102 degrees C. Comparison of homologues was made between low-temperature species and high-temperature species within each subset. We found that unspecific interactions like hydrophobic interactions in the core and solvent interactions and entropic effects at the surface, appear to be more important factors than specific contact types like salt bridges and aromatic clusters. |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 3% |
| Italy | 1 | 1% |
| Netherlands | 1 | 1% |
| Sweden | 1 | 1% |
| Estonia | 1 | 1% |
| Unknown | 87 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 28% |
| Researcher | 19 | 20% |
| Professor | 10 | 11% |
| Student > Bachelor | 10 | 11% |
| Student > Master | 8 | 9% |
| Other | 12 | 13% |
| Unknown | 9 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 40% |
| Biochemistry, Genetics and Molecular Biology | 28 | 30% |
| Chemistry | 4 | 4% |
| Physics and Astronomy | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 7 | 7% |
| Unknown | 10 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2009.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from Extremophiles
#543
of 799 outputs
Outputs of similar age
#75,159
of 88,597 outputs
Outputs of similar age from Extremophiles
#5
of 5 outputs
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So far Altmetric has tracked 799 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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