| Title |
A Comparative Study on the Ability of Two Implicit Solvent Lipid Models to Predict Transmembrane Helix Tilt Angles
|
|---|---|
| Published in |
The Journal of Membrane Biology, December 2010
|
| DOI | 10.1007/s00232-010-9325-7 |
| Pubmed ID | |
| Authors |
Aaron Frank, Ioan Andricioaei |
| Abstract |
Free-energy profiles describing the relative orientation of membrane proteins along predefined coordinates can be efficiently calculated by means of umbrella simulations. Such simulations generate reliable orientational distributions but are difficult to converge because of the very long equilibration times of the solvent and the lipid bilayer in explicit representation. Two implicit lipid membrane models are here applied in combination with the umbrella sampling strategy to the simulation of the transmembrane (TM) helical segment from virus protein U (Vpu). The models are used to study both orientation and energetics of this α-helical peptide as a function of hydrophobic mismatch. We observe that increasing the degree of positive hydrophobic mismatch increased the tilt angle of Vpu. These findings agree well with experimental data and as such validate the solvation models used in this study. |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 8% |
| Canada | 1 | 4% |
| Unknown | 22 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 32% |
| Student > Ph. D. Student | 7 | 28% |
| Student > Bachelor | 4 | 16% |
| Other | 1 | 4% |
| Student > Doctoral Student | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 36% |
| Chemistry | 5 | 20% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Computer Science | 2 | 8% |
| Physics and Astronomy | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2011.
All research outputs
#16,042,980
of 23,806,312 outputs
Outputs from The Journal of Membrane Biology
#616
of 803 outputs
Outputs of similar age
#145,250
of 185,159 outputs
Outputs of similar age from The Journal of Membrane Biology
#6
of 8 outputs
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So far Altmetric has tracked 803 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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