Title |
MOG1
|
---|---|
Published in |
Circulation: Genomic and Precision Medicine, March 2011
|
DOI | 10.1161/circgenetics.110.959130 |
Pubmed ID | |
Authors |
Darouna Kattygnarath, Svetlana Maugenre, Nathalie Neyroud, Elise Balse, Carole Ichai, Isabelle Denjoy, Gilles Dilanian, Raphaël P. Martins, Véronique Fressart, Myriam Berthet, Jean Jacques Schott, Antoine Leenhardt, Vincent Probst, Hervé Le Marec, Bernard Hainque, Alain Coulombe, Stéphane N. Hatem, Pascale Guicheney |
Abstract |
Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene, which encodes the α-subunit of the cardiac sodium channel Na(v)1.5. However, ≈ 20% of probands have SCN5A mutations, suggesting the implication of other genes. MOG1 recently was described as a new partner of Na(v)1.5, playing a potential role in the regulation of its expression and trafficking. We investigated whether mutations in MOG1 could cause BrS. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 3% |
Chile | 1 | 1% |
Switzerland | 1 | 1% |
Unknown | 71 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 20% |
Student > Ph. D. Student | 11 | 15% |
Student > Master | 10 | 13% |
Student > Bachelor | 7 | 9% |
Other | 7 | 9% |
Other | 11 | 15% |
Unknown | 14 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 43% |
Agricultural and Biological Sciences | 15 | 20% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Sports and Recreations | 1 | 1% |
Neuroscience | 1 | 1% |
Other | 2 | 3% |
Unknown | 16 | 21% |