| Title |
Lymphangiogenesis in Crohn’s disease: an immunohistochemical study using monoclonal antibody D2-40
|
|---|---|
| Published in |
Virchows Archiv, November 2007
|
| DOI | 10.1007/s00428-007-0540-2 |
| Pubmed ID | |
| Authors |
F. Pedica, C. Ligorio, P. Tonelli, S. Bartolini, P. Baccarini |
| Abstract |
Crohn's disease (CD) is a chronic inflammatory bowel disorder of unknown etiology. An involvement of the intestinal lymphatic system has been suggested. Recently, monoclonal antibodies have become available to distinguish lymphatic vessels from blood vessels. The aim of the study was to examine the distribution of lymphatic vessels in ileal and colic walls of patients affected by CD and compare it with healthy controls and other inflammatory bowel diseases. Twenty-eight cases of CD, 13 cases of other inflammatory bowel diseases, and 10 normal ileal and colic walls were studied. Immunohistochemical staining was performed using the monoclonal antibody D2-40. Quantification of lymphatic vessels was performed by identifying four fields with high density of lymphatics and then counting the number of lymphatic vessels at high resolution. Lymphatic diameter was also evaluated by using an ocular micrometer. Lymphatic vessels showed the highest density in CD specimens. The median number of lymphatics was significantly higher both in ileal and colic samples of CD than the other inflammatory diseases as well as normal controls. Moreover, in patients with CD, diffuse lymphangiectasia was also observed. The present data suggest that lymphangiogenesis and lymphangiectasia probably play a role in the pathogenesis of CD. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 3% |
| Unknown | 29 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 20% |
| Student > Master | 4 | 13% |
| Researcher | 4 | 13% |
| Student > Doctoral Student | 3 | 10% |
| Student > Bachelor | 3 | 10% |
| Other | 7 | 23% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 27% |
| Biochemistry, Genetics and Molecular Biology | 5 | 17% |
| Agricultural and Biological Sciences | 5 | 17% |
| Immunology and Microbiology | 4 | 13% |
| Engineering | 3 | 10% |
| Other | 3 | 10% |
| Unknown | 2 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2008.
All research outputs
#15,241,259
of 22,661,413 outputs
Outputs from Virchows Archiv
#1,268
of 1,934 outputs
Outputs of similar age
#131,080
of 155,829 outputs
Outputs of similar age from Virchows Archiv
#5
of 6 outputs
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