Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Ganesh Chauhan, Hieab H.H. Adams, Claudia L. Satizabal, Joshua C. Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L. Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W. Beecham, Thomas J. Montine, Gerard D. Schellenberg, Olafur Kjartansson, Vilmundur Guðnason, David S. Knopman, Michael E. Griswold, B. Gwen Windham, Rebecca F. Gottesman, Thomas H. Mosley, Reinhold Schmidt, Yasaman Saba, Helena Schmidt, Fumihiko Takeuchi, Shuhei Yamaguchi, Toru Nabika, Norihiro Kato, Kumar B. Rajan, Neelum T. Aggarwal, Philip L. De Jager, Denis A. Evans, Bruce M. Psaty, Jerome I. Rotter, Kenneth Rice, Oscar L. Lopez, Jiemin Liao, Christopher Chen, Ching-Yu Cheng, Tien Y. Wong, Mohammad K. Ikram, Sven J. van der Lee, Najaf Amin, Vincent Chouraki, Anita L. DeStefano, Hugo J. Aparicio, Jose R. Romero, Pauline Maillard, Charles DeCarli, Joanna M. Wardlaw, Maria del C. Valdés Hernández, Michelle Luciano, David Liewald, Ian J. Deary, John M. Starr, Mark E. Bastin, Susana Muñoz Maniega, P. Eline Slagboom, Marian Beekman, Joris Deelen, Hae-Won Uh, Robin Lemmens, Henry Brodaty, Margaret J. Wright, David Ames, Giorgio B. Boncoraglio, Jemma C. Hopewell, Ashley H. Beecham, Susan H. Blanton, Clinton B. Wright, Ralph L. Sacco, Wei Wen, Anbupalam Thalamuthu, Nicola J. Armstrong, Elizabeth Chong, Peter R. Schofield, John B. Kwok, Jeroen van der Grond, David J. Stott, Ian Ford, J. Wouter Jukema, Meike W. Vernooij, Albert Hofman, André G. Uitterlinden, Aad van der Lugt, Katharina Wittfeld, Hans J. Grabe, Norbert Hosten, Bettina von Sarnowski, Uwe Völker, Christopher Levi, Jordi Jimenez-Conde, Pankaj Sharma, Cathie L.M. Sudlow, Jonathan Rosand, Daniel Woo, John W. Cole, James F. Meschia, Agnieszka Slowik, Vincent Thijs, Arne Lindgren, Olle Melander, Raji P. Grewal, Tatjana Rundek, Kathy Rexrode, Peter M. Rothwell, Donna K. Arnett, Christina Jern, Julie A. Johnson, Oscar R. Benavente, Sylvia Wasssertheil-Smoller, Jin-Moo Lee, Quenna Wong, Braxton D. Mitchell, Stephen S. Rich, Patrick F. McArdle, Mirjam I. Geerlings, Yolanda van der Graaf, Paul I.W. de Bakker, Folkert W. Asselbergs, Velandai Srikanth, Russell Thomson, Rebekah McWhirter, Chris Moran, Michele Callisaya, Thanh Phan, Loes C.A. Rutten-Jacobs, Steve Bevan, Christophe Tzourio, Karen A. Mather, Perminder S. Sachdev, Cornelia M. van Duijn, Bradford B. Worrall, Martin Dichgans, Steven J. Kittner, Hugh S. Markus, Mohammad A. Ikram, Myriam Fornage, Lenore J. Launer, Sudha Seshadri, W.T. Longstreth, Stéphanie Debette, METASTROKE the International Stroke Genetics Consortium, Peter Almgren, Christopher D. Anderson, Donna K. Arnett, John Attia, Hakan Ay, Oscar R. Benavente, Steve Bevan, Robert D. Brown, Mariana Bustamante, Yu-Ching Cheng, John W. Cole, Ioana Cotlarciuc, Carlos Cruchaga, Paul IW. de Bakker, Hossein Delavaran, Martin Dichgans, Gunnar Engström, Myriam Fornage, Raji P. Grewal, Laura Heitsch, Elizabeth Holliday, Laure Ibanez, Andreea Ilinca, Marguerite R. Irvin, Rebecca D. Jackson, Christina Jern, Jordi Jimenez-Conde, Julie A. Johnson, Katarina Jood, Brett M. Kissela, Steven J. Kittner, Dawn O. Kleindorfer, Daniel Labovitz, Cathy C. Laurie, Jin-Moo Lee, Robin Lemmens, Christopher Levi, Linxin Li, Arne G. Lindgren, Jane Maguire, Hugh S. Markus, Patrick F. McArdle, Olle Melander, James F. Meschia, Braxton D. Mitchell, Martina Müller-Nurasyid, Bo Norrving, Leema Reddy Peddareddygari, Joanna Pera, Sara L. Pulit, Kathryn Rexrode, Marta Ribasés, Jaume Roquer, Natalia S. Rost, Peter M. Rothwell, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Carolina Soriano-Tárraga, Tara Stanne, Konstantin Stauch, O C. Stine, Cathie LM. Sudlow, Vincent N.S. Thijs, Sylvia Wasssertheil-Smoller, David Weir, Stephen R. Williams, Quenna Wong, Daniel Woo, Bradford B. Worrall, Huichun Xu, Sudha Seshadri, Hyacinth I Hyacinth, Sandro Marini, Paul Nyquist, Cathryn Lewis, Bjorn Hansen, Bo Norrving, Jonathan Rosand, Alessandro Biffi, Christina Kourkoulis, Chris Anderson, Anne-Katrin Giese, Ralph Sacco, Pankaj Sharma, Jong-Won Chung, Gyeong-Moon Kim, Steven Lubitz, Romain Bourcier, Joanna Howson, Alessandra Granata, Anna Drazyk, Hugh Markus, Joanna Wardlaw, Braxton Mitchell, John Cole, Jemma Hopewell, Robin Walters, Iain Turnbull, Bradford Worrall, Josh Bis, Alex Reiner, Raj Dhar, Laura Heitsch, Jin-Moo Lee, Kameshwar Prasad, Chloé Sarnowski, Hugo Javier Aparicio, Qiong Yang, Daniel Chasman, Kathryn Rexrode, Chia-Ling Phuah, Guiyou Liu, Mitchell Elkind, Leslie Lange, Natalia Rost, Michael James, Jill Stewart, Dina Vojinovic, Vincent Thijs, Eugenio Parati, Giorgio Boncoraglio, Ramin Zand, Philippe Bijlenga, Magdy Selim, Caspar Grond-Ginsbach, Daniel Strbian, Liisa Tomppo, Hanne Sallinen, Dorothea Pfeiffer, Nuria Torres, Miguel Barboza, Melanie Laarman, Roberta Carriero, Elizabeth Holliday, Jordi Jimenez-Conde, Carolina Soriano, Dipender Gill, Stephanie Debette, Aniket Mishra, Jer-Yuarn Wu, Tai-Ming Ko, Silvia Bione, Katarina Jood, Turgut Tatlisumak, Lukas Holmegaard, Suo Yue, Anna bersano, Joanna Pera, Agnieszka Slowik, Christopher Levi, Kristina Schlicht, Robin Lemmens, Toshiharu Ninomiya, Saskia Lesnik Oberstein, Tsong-Hai Lee, Rainer Malik, Martin Dichgans, Arne Lindgren, Johan Wasselius, Mattias Drake, Olle Melander, Martin Stenman, Andreea Ilinca, Katherine Crawford, Umme Lena, Farrah Mateen, Hakan Ay, Ona Wu, Markus Schirmer, Steve Cramer, Polina Golland, Robert Brown, James Meschia, Owen A. Ross, Guillaume Pare, Mike Chong, Tatjana Rundek, Katrina Gwinn, Christopher Chen, Jim Koenig, Eva Giralt, Danish Saleheen, Frank-Erik de Leeuw, Karin Klijn, Yoichiro Kamatani, Michiaki Kubo, Yukinori Okada, Annie Pedersen, Maja Olsson, Juan José Martín, Huichun Xu, Eng King Tan, Petrea Frid, Chaeyoung Lee, David Tregouet, Thomas Leung, Richard Choy, Christina Jern, Keat Wei Loo, Gabriel Rinkel, Paulo Franca, Iscia Cendes, Caty Carrera, Israel Fernandez-Cadenas, Joan Montaner, Helen Kim, Mayowa Owolabi, Reecha Sofat, Mark Bakker, Ynte Ruigrok, Allard Hauer, Sara L. Pulit, Sander W. van der Laan, Ryan Irvin, Murali Sargurupremraj, Alessandro Pezzini, Foad Abd-Allah, David Liebeskind, Matthew Traylor, Rhea Tan, John Danesh, Loes Rutten-Jacobs, Amanda Donatti, Wagner Avelar, Joseph Broderick, Daniel Woo, Cathie Sudlow, Kristiina Rannikmae, Caitrin Wheeler McDonough, Tom van Agtmael, Matthew Walters, Martin Söderholm, Erik Lorentzen, Sandra Olsson, Tara Stanne, Martina Olsson, Rufus Akinyemi, Ioana Cotlatciuc, Patrick McArdle, Tushar Dave, Steven Kittner, John Attia, James E Faber, Iona Millwood, Elsa Valdés Márquez, Michelangelo Mancuso, Riina Vibo, Janika Korv, Jane Maguire, Myriam Fornage, Jennifer Majersik, Adam DeHavenon, Matthew Alexander, Michele Sale, Andrew Southerland, Debra Owens, Bruce Psaty, W. T. Longstreth, Stacey Quintero Wolfe, Carl Langefeld, Carlos Cruchaga, Jan Konrad, Kevin Sheth, Guido Falcone, Kathleen Donahue, Alexis N Simpkins, Tan Wei Liang Byorn, Bernard Chan, Phil Clatworthy, Jose Florez, Eric Harshfield, Atsushi Hozawa, Chung Hsu, Chaur-Jong Hu, Laure Ibanez, Masafumi Ihara, Marcos Lange, Soo Ji Lee, I-Hui Lee, Patricia Musolino, Hirofumi Nakatomi, Kwang-Yeol Park, Stephen S Rich, Chris Riley, Joohon Sung, Hideaki Suzuki, Katie Vo, Kazuo Washida, Laura Garcia Ibenez, Agnieszka Slowik, Albert Hofman, Ale Algra, Alex P Reiner, Alexander S F Doney, Andreas Gschwendtner, Andreea Ilinca, Anne-Katrin Giese, Arne Lindgren, Astrid M Vicente, Bo Norrving, Børge G Nordestgaard, Braxton D Mitchell, Bradford B Worrall, Bruce M Psaty, Cara L Carty, Cathie Sudlow, Christopher D Anderson, Christopher Levi, Claudia L Satizabal, Colin N A Palmer, Dale M Gamble, Daniel Woo, Danish Saleheen, E Bernd Ringelstein, Einar Valdimarsson, Elizabeth Holliday, Gail Davies, Ganesh Chauhan, Gerard Pasterkamp, Giorgio Boncoraglio, Gregor Kuhlenbäumer, Gudmar Thorleifsson, Guido J Falcone, Guillame Pare, Helena Schmidt, Hossein Delavaran, Hugh S Markus, Hugo J Aparicio, Ian Deary, Ioana Cotlarciuc, Israel Fernandez-Cadenas, James Meschia, Jemma C Hopewell, Jingmin Liu, Joan Montaner, Joanna Pera, John Cole, John R Attia, Jonathan Rosand, Jose M Ferro, Joshua Bis, Karen Furie, Kari Stefansson, Klaus Berger, Konstantinos Kostulas, Kristina Rannikmae, M Arfan Ikram, Marianne Benn, Martin Dichgans, Martin Farrall, Massimo Pandolfo, Matthew Traylor, Matthew Walters, Michele Sale, Mike Nalls, Myriam Fornage, Natalie R van Zuydam, Pankaj Sharma, Patricia Abrantes, Paul IW de Bakker, Peter Higgins, Peter Lichtner, Peter M Rothwell, Philippe Amouyel, Qiong Yang, Rainer Malik, Reinhold Schmidt, Robert Clarke, Robin Lemmens, Sander W van der Laan, Sara L Pulit, Sherine Abboud, Sofia A Oliveira, Solveig Gretarsdottir, Stephanie Debette, Stephen R Williams, Steve Bevan, Steven J Kittner, Sudha Seshadri, Thomas Mosley, Thomas WK Battey, Turgut Tatlisumak, Unnur Thorsteinsdottir, Vincent NS Thijs, W T Longstreth, Wei Zhao, Wei-Min Chen, Yu-Ching Cheng, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig S. Atwood, Clinton T. Baldwin, M. Michael Barmada, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, David A. Bennett, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, Adam Boxer, James R. Burke, Jeffrey M. Burns, Joseph D. Buxbaum, Goldie S. Byrd, Guiqing Cai, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Steven L. Carroll, Helena C. Chui, David G. Clark, David H. Cribbs, Elizabeth A. Crocco, Carlos Cruchaga, Philip L. De Jager, Charles DeCarli, F. Yesim Demirci, Malcolm Dick, Dennis W. Dickson, Ranjan Duara, Nilufer Ertekin-Taner, Denis A. Evans, Kelley M. Faber, M. Daniele Fallin, Kenneth B. Fallon, David W. Fardo, Martin R. Farlow, Lindsay A. Farrer, Steven Ferris, Tatiana M. Foroud, Matthew P. Frosch, Douglas R. Galasko, Marla Gearing, Daniel H. 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Morris, Jill R. Murrell, Adam C. Naj, Thomas O. Obisesan, John M. Olichney, Vernon S. Pankratz, Joseph E. Parisi, Amanda Partch, Henry L. Paulson, Margaret A. Pericak-Vance, William Perry, Elaine Peskind, Ronald C. Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Towfique Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, Christiane Reitz, John M. Ringman, Erik D. Roberson, Howard J. Rosen, Roger N. Rosenberg, Mark A. Sager, Mary Sano, Andrew J. Saykin, Gerard D. Schellenberg, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda G. Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Russell H. Swerdlow, Rudolph E. Tanzi, Tricia A. Thornton-Wells, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Otto Valladares, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Li-San Wang, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Jennifer Williamson, Thomas S. Wingo, Sarah Wishnek, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang-En Yu, Lei Yu, Ganesh Chauhan, Audrey Y. Chu, Myriam Fornage, Joshua C. Bis, Aki S. Havulinna, Muralidharan Sargurupremraj, Albert Vernon Smith, Hieab H.H. Adams, Seung Hoan Choi, Stella Trompet, Melissa E. Garcia, Ani Manichaikul, Alexander Teumer, Stefan Gustafsson, Traci M. Bartz, Céline Bellenguez, Jean Sebastien Vidal, Xueqiu Jian, Olafur Kjartansson, Kerri L. Wiggins, Claudia L. Satizabal, Flora Xue, Samuli Ripatti, Yongmei Liu, Joris Deelen, Marcel den Hoed, Susan R. Heckbert, Kenneth Rice, Nicholas L. Smith, Quenna Wong, Hugo J. Aparicio, Julie E. Buring, Paul M Ridker, Claudine Berr, Jean-François Dartigues, Anders Hamsten, Patrik K. Magnusson, Nancy L. Pedersen, Lars Lannfelt, Lars Lind, Cecilia M. Lindgren, Andrew P. Morris, Albert Hofman, Peter J. Koudstaal, Marileen LP. Portegies, André G. Uitterlinden, Anton JM de Craen, Ian Ford, J. Wouter Jukema, David J Stott, Norrina B. Allen, Michele M. Sale, Andrew D Johnson, David A. Bennett, Philip L. De Jager, Charles C. White, Hans Jörgen Grabe, Marcello Ricardo Paulista Markus, Oscar L Lopez, Jerome I. Rotter, Michael A. Nalls, Rebecca F. Gottesman, Michael E. Griswold, David S. Knopman, B. Gwen Windham, Alexa Beiser, Erkki Vartiainen, Curtis R. French, Tobias Kurth, Bruce M. Psaty, Tamara B. Harris, Stephen S Rich, Anita L. deStefano, Carsten Oliver Schmidt, Veikko Salomaa, Thomas H. Mosley, Erik Ingelsson, Cornelia M. van Duijn, Christophe Tzourio, Lenore J Launer, M. Arfan Ikram, Daniel I. Chasman, W. T. Longstreth, Sudha Seshadri, Stéphanie Debette, Benjamin F.J. Verhaaren, Stéphanie Debette, Joshua C. Bis, Jennifer A. Smith, M. Kamran Ikram, Hieab H. Adams, Ashley H. Beecham, Kumar B. Rajan, Lorna M. Lopez, Sandra Barral, Mark A. van Buchem, Jeroen van der Grond, Albert V. Smith, Katrin Hegenscheid, Neelum T. Aggarwal, Mariza de Andrade, Elizabeth J. Atkinson, Marian Beekman, Alexa S. Beiser, Susan H. Blanton, Eric Boerwinkle, Adam M. Brickman, R. Nick Bryan, Ganesh Chauhan, Christopher P.L.H. Chen, Vincent Chouraki, Anton J.M. de Craen, Fabrice Crivello, Ian J. Deary, Joris Deelen, Philip L. De Jager, Carole Dufouil, Mitchell S.V. Elkind, Denis A. Evans, Paul Freudenberger, Rebecca F. Gottesman, Vilmundur Guðnason, Mohamad Habes, Susan R. Heckbert, Gerardo Heiss, Saima Hilal, Edith Hofer, Albert Hofman, Carla A. Ibrahim-Verbaas, David S. Knopman, Cora E. Lewis, Jiemin Liao, David C.M. Liewald, Michelle Luciano, Aad van der Lugt, Oliver O. Martinez, Richard Mayeux, Bernard Mazoyer, Mike Nalls, Matthias Nauck, Wiro J. Niessen, Ben A. Oostra, Bruce M. Psaty, Kenneth M. Rice, Jerome I. Rotter, Bettina von Sarnowski, Helena Schmidt, Pamela J. Schreiner, Maaike Schuur, Stephen S. Sidney, Sigurdur Sigurdsson, P. Eline Slagboom, David J.M. Stott, John C. van Swieten, Alexander Teumer, Anna Maria Töglhofer, Matthew Traylor, Stella Trompet, Stephen T. Turner, Christophe Tzourio, Hae-Won Uh, André G. Uitterlinden, Meike W. Vernooij, Jing J. Wang, Tien Y. Wong, Joanna M. Wardlaw, B. Gwen Windham, Katharina Wittfeld, Christiane Wolf, Clinton B. Wright, Qiong Yang, Wei Zhao, Alex Zijdenbos, J. Wouter Jukema, Ralph L. Sacco, Sharon L.R. Kardia, Philippe Amouyel, Thomas H. Mosley, W. T. Longstreth, Charles C. DeCarli, Cornelia M. van Duijn, Reinhold Schmidt, Lenore J. Launer, Hans J. Grabe, Sudha S. Seshadri, M. Arfan Ikram, Myriam Fornage, Joshua C. Bis, Maryam Kavousi, Nora Franceschini, Aaron Isaacs, Gonçalo R Abecasis, Ulf Schminke, Wendy Post, Albert V. Smith, L. Adrienne Cupples, Hugh S Markus, Reinhold Schmidt, Jennifer E. Huffman, Terho Lehtimäki, Jens Baumert, Thomas Münzel, Susan R. Heckbert, Abbas Dehghan, Kari North, Ben Oostra, Steve Bevan, Eva-Maria Stoegerer, Caroline Hayward, Olli Raitakari, Christa Meisinger, Arne Schillert, Serena Sanna, Henry Völzke, Yu-Ching Cheng, Bolli Thorsson, Caroline S. Fox, Kenneth Rice, Fernando Rivadeneira, Vijay Nambi, Eran Halperin, Katja E. Petrovic, Leena Peltonen, H. Erich Wichmann, Renate B. Schnabel, Marcus Dörr, Afshin Parsa, Thor Aspelund, Serkalem Demissie, Sekar Kathiresan, Muredach P. Reilly, Kent Taylor, Andre Uitterlinden, David J. Couper, Matthias Sitzer, Mika Kähönen, Thomas Illig, Philipp S. Wild, Marco Orru, Jan Lüdemann, Alan R. Shuldiner, Gudny Eiriksdottir, Charles C. White, Jerome I. Rotter, Albert Hofman, Jochen Seissler, Tanja Zeller, Gianluca Usala, Florian Ernst, Lenore J. Launer, Ralph B. D'Agostino, Daniel H. O'Leary, Christie Ballantyne, Joachim Thiery, Andreas Ziegler, Edward G. Lakatta, Ravi Kumar Chilukoti, Tamara B. Harris, Philip A. Wolf, Bruce M. Psaty, Joseph F Polak, Xia Li, Wolfgang Rathmann, Manuela Uda, Eric Boerwinkle, Norman Klopp, Helena Schmidt, James F Wilson, Jorma Viikari, Wolfgang Koenig, Stefan Blankenberg, Anne B. Newman, Jacqueline Witteman, Gerardo Heiss, Cornelia van Duijn, Angelo Scuteri, Georg Homuth, Braxton D. Mitchell, Vilmundur Gudnason, Christopher J. O’Donnell