Title |
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
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Published in |
Nature Medicine, August 2009
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DOI | 10.1038/nm.2000 |
Pubmed ID | |
Authors |
Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman |
Abstract |
Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellular changes that occur in BRCA1 mutation carriers, we have prospectively isolated distinct epithelial subpopulations from normal mammary tissue and preneoplastic specimens from individuals heterozygous for a BRCA1 mutation. We describe three epithelial subsets including basal stem/progenitor, luminal progenitor and mature luminal cells. Unexpectedly, we found that breast tissue from BRCA1 mutation carriers harbors an expanded luminal progenitor population that shows factor-independent growth in vitro. Moreover, gene expression profiling revealed that breast tissue heterozygous for a BRCA1 mutation and basal breast tumors were more similar to normal luminal progenitor cells than any other subset, including the stem cell-enriched population. The c-KIT tyrosine kinase receptor (encoded by KIT) emerged as a key marker of luminal progenitor cells and was more highly expressed in BRCA1-associated preneoplastic tissue and tumors. Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors . |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | <1% |
United Kingdom | 4 | <1% |
Spain | 3 | <1% |
Norway | 2 | <1% |
Australia | 1 | <1% |
Canada | 1 | <1% |
Netherlands | 1 | <1% |
Denmark | 1 | <1% |
Portugal | 1 | <1% |
Other | 2 | <1% |
Unknown | 709 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 170 | 23% |
Researcher | 164 | 22% |
Student > Master | 86 | 12% |
Student > Bachelor | 55 | 8% |
Professor > Associate Professor | 36 | 5% |
Other | 109 | 15% |
Unknown | 112 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 250 | 34% |
Biochemistry, Genetics and Molecular Biology | 172 | 23% |
Medicine and Dentistry | 98 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 20 | 3% |
Immunology and Microbiology | 11 | 2% |
Other | 51 | 7% |
Unknown | 130 | 18% |