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Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Overview of attention for article published in Nature Medicine, August 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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1 X user
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Citations

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1205 Dimensions

Readers on

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732 Mendeley
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3 CiteULike
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3 Connotea
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Title
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Published in
Nature Medicine, August 2009
DOI 10.1038/nm.2000
Pubmed ID
Authors

Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman

Abstract

Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellular changes that occur in BRCA1 mutation carriers, we have prospectively isolated distinct epithelial subpopulations from normal mammary tissue and preneoplastic specimens from individuals heterozygous for a BRCA1 mutation. We describe three epithelial subsets including basal stem/progenitor, luminal progenitor and mature luminal cells. Unexpectedly, we found that breast tissue from BRCA1 mutation carriers harbors an expanded luminal progenitor population that shows factor-independent growth in vitro. Moreover, gene expression profiling revealed that breast tissue heterozygous for a BRCA1 mutation and basal breast tumors were more similar to normal luminal progenitor cells than any other subset, including the stem cell-enriched population. The c-KIT tyrosine kinase receptor (encoded by KIT) emerged as a key marker of luminal progenitor cells and was more highly expressed in BRCA1-associated preneoplastic tissue and tumors. Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors .

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 732 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 <1%
United Kingdom 4 <1%
Spain 3 <1%
Norway 2 <1%
Australia 1 <1%
Canada 1 <1%
Netherlands 1 <1%
Denmark 1 <1%
Portugal 1 <1%
Other 2 <1%
Unknown 709 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 170 23%
Researcher 164 22%
Student > Master 86 12%
Student > Bachelor 55 8%
Professor > Associate Professor 36 5%
Other 109 15%
Unknown 112 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 250 34%
Biochemistry, Genetics and Molecular Biology 172 23%
Medicine and Dentistry 98 13%
Pharmacology, Toxicology and Pharmaceutical Science 20 3%
Immunology and Microbiology 11 2%
Other 51 7%
Unknown 130 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2024.
All research outputs
#3,242,679
of 25,263,619 outputs
Outputs from Nature Medicine
#4,660
of 9,257 outputs
Outputs of similar age
#12,009
of 118,658 outputs
Outputs of similar age from Nature Medicine
#27
of 66 outputs
Altmetric has tracked 25,263,619 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,257 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 104.7. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,658 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.