| Title |
Histological heterogeneity of Ewing’s sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support
|
|---|---|
| Published in |
Virchows Archiv, October 2009
|
| DOI | 10.1007/s00428-009-0842-7 |
| Pubmed ID | |
| Authors |
Antonio Llombart-Bosch, Isidro Machado, Samuel Navarro, Franco Bertoni, Patrizia Bacchini, Marco Alberghini, Apollon Karzeladze, Nikita Savelov, Semyon Petrov, Isabel Alvarado-Cabrero, Doina Mihaila, Philippe Terrier, Jose Antonio Lopez-Guerrero, Piero Picci |
| Abstract |
Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) are malignant neoplasms affecting children and young adults. We performed a study to typify the histological diversity and evaluate antibodies that may offer diagnostic/prognostic support. In total, 415 cases of genetically confirmed paraffin-embedded ES/PNET were analyzed on whole sections and in tissue microarrays. This study confirms the structural heterogeneity of ES/PNET, distinguishing three major subtypes: conventional ES (280 cases); PNET (53 cases); and atypical ES/PNET (80), including large cells, vascular-like patterns, spindle pattern, and adamantinoma-like configuration. All cases presented positivity for at least three of the four tested antibodies (CD99, FLI1, HNK1, and CAV1). CAV1 appeared as a diagnostic immunomarker of ES/PNET being positive in CD99-negative cases. Hence, the immunohistochemical analysis confirmed the diagnostic value of all four antibodies, which together cover more than 99% of the tumors, independently of the histological variety. The univariate analysis for survival revealed atypical ES as the only histological parameter apparently associated with less favorable clinical outcome, particularly in the subgroup of patients treated with surgery. In conclusion, the diagnosis of atypical ES is a challenge for the pathologist and needs support from molecular techniques to perform an optimal differential diagnosis with other small round cell tumors. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Hong Kong | 1 | 1% |
| Unknown | 85 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 16 | 18% |
| Student > Bachelor | 13 | 14% |
| Student > Ph. D. Student | 8 | 9% |
| Student > Postgraduate | 7 | 8% |
| Researcher | 6 | 7% |
| Other | 24 | 27% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 53% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Agricultural and Biological Sciences | 4 | 4% |
| Unspecified | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 17 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2019.
All research outputs
#14,142,336
of 22,661,413 outputs
Outputs from Virchows Archiv
#1,122
of 1,934 outputs
Outputs of similar age
#75,908
of 93,041 outputs
Outputs of similar age from Virchows Archiv
#7
of 8 outputs
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