| Title |
In vitro assessment of the biological response to nano-sized hydroxyapatite
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, April 2004
|
| DOI | 10.1023/b:jmsm.0000021117.67205.cf |
| Pubmed ID | |
| Authors |
J. Huang, S. M. Best, W. Bonfield, R. A. Brooks, N. Rushton, S. N. Jayasinghe, M. J. Edirisinghe |
| Abstract |
Nano-sized, rod-like hydroxyapatite (nHA) crystals were produced and shown to be phasepure by X-ray diffraction analysis, as no secondary phases were observed. The nHA suspension was electrosprayed onto glass substrates using a novel processing routine to maintain nanocrystals of hydroxyapatite. The biocompatibility of nHAwas determined using human monocyte-derived macrophages and human osteoblast-like (HOB) cell models. The release of lactate dehydrogenase (LDH) from human monocyte-derived macrophages was measured as an indicator of cytotoxicity. The release of the inflammatory cytokine, tumour necrosis factor alpha (TNF-alpha) from cells in the presence of nHA crystallites was used as a measure of the inflammatory response. Although there was some evidence of LDH release from human monocyte-derived macrophages when in contact with high concentrations of nHA crystals, there was no significant release of TNF-alpha. Moreover, nHA-sprayed substrates were able to support the attachment and the growth of HOB cells. These results indicate that nHA crystals may be suitable for intraosseous implantation and offers the potential to formulate enhanced composites for biomedical applications. |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| United Kingdom | 1 | 1% |
| Sweden | 1 | 1% |
| Unknown | 80 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 24% |
| Researcher | 11 | 13% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 6 | 7% |
| Student > Doctoral Student | 5 | 6% |
| Other | 16 | 19% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 17 | 20% |
| Materials Science | 14 | 17% |
| Medicine and Dentistry | 12 | 14% |
| Chemistry | 5 | 6% |
| Physics and Astronomy | 3 | 4% |
| Other | 10 | 12% |
| Unknown | 22 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2015.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#344
of 1,506 outputs
Outputs of similar age
#21,863
of 64,942 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#7
of 24 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,506 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 64,942 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.