| Title |
Meta-analysis of vitamin D, calcium and the prevention of breast cancer
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, October 2009
|
| DOI | 10.1007/s10549-009-0593-9 |
| Pubmed ID | |
| Authors |
Peizhan Chen, Pingting Hu, Dong Xie, Ying Qin, Fudi Wang, Hui Wang |
| Abstract |
Vitamin D and calcium intake have been suggested to have protective effects against breast cancer; however, the data have been inconclusive. The present meta-analysis examined the overall effects of vitamin D intake, circulating 25(OH)D and 1alpha,25(OH)(2)D levels, and calcium intake on breast cancer risk. Data from 11 studies on vitamin D intake, 7 studies on circulating 25(OH)D levels, 3 studies of circulating 1alpha,25(OH)(2)D levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. From the meta-analysis, there was a significant inverse relationship between vitamin D intake and breast cancer risk, with an overall relative risk (RR) of high versus low vitamin D intake for breast cancer of 0.91 (95% CI = 0.85-0.97). The highest quantile of circulating 25(OH)D was found to be associated with a 45% (OR = 0.55, 95% CI = 0.38-0.80) decrease in breast cancer when compared with the lowest quantile. No significant association for the circulating 1alpha,25(OH)(2)D level and breast cancer was found (OR = 0.99, 95% CI = 0.68-1.44). For calcium, a 19% (RR = 0.81, 95% CI = 0.72-0.90) decrease in breast cancer risk was found for those with highest quantile of calcium intake compared to the lowest quantile. These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 176 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 36 | 20% |
| Researcher | 22 | 12% |
| Student > Master | 20 | 11% |
| Student > Ph. D. Student | 19 | 11% |
| Other | 11 | 6% |
| Other | 41 | 23% |
| Unknown | 31 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 32% |
| Agricultural and Biological Sciences | 28 | 16% |
| Biochemistry, Genetics and Molecular Biology | 16 | 9% |
| Nursing and Health Professions | 12 | 7% |
| Social Sciences | 6 | 3% |
| Other | 22 | 12% |
| Unknown | 38 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2023.
All research outputs
#6,277,329
of 24,719,968 outputs
Outputs from Breast Cancer Research and Treatment
#1,355
of 4,906 outputs
Outputs of similar age
#28,740
of 100,381 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#14
of 46 outputs
Altmetric has tracked 24,719,968 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 4,906 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,381 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.