↓ Skip to main content

Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin

Overview of attention for article published in Molecular Cell, November 2003
Altmetric Badge

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
232 Dimensions

Readers on

mendeley
165 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin
Published in
Molecular Cell, November 2003
DOI 10.1016/s1097-2765(03)00438-6
Pubmed ID
Authors

Helena Santos-Rosa, Robert Schneider, Bradley E. Bernstein, Nickoletta Karabetsou, Antonin Morillon, Christoph Weise, Stuart L. Schreiber, Jane Mellor, Tony Kouzarides

Abstract

Set1p methylates lysine 4 (K4) of histone H3 and regulates the expression of many genes in yeast. Here we use a biochemical approach to identify a protein, Isw1p, which recognizes chromatin preferentially when it is di- and trimethylated at K4 H3. We show that on certain actively transcribed genes, the Isw1p chromatin remodeling ATPase requires K4 H3 methylation to associate with chromatin in vivo. Analysis of one such gene, MET16, shows that the enzymatic activities of Set1p and Isw1p are functionally connected: Set1p methylation and Isw1p ATPase generate specific chromatin changes at the 5' end of the gene, are necessary for the correct distribution of RNA polymerase II over the coding region, and are required for the recruitment of the cleavage and polyadenylation factor Rna15p. These results indicate that K4 H3 methylation and Isw1p ATPase activity are intimately linked in regulating transcription of certain genes in yeast.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 1%
Netherlands 2 1%
Japan 2 1%
France 2 1%
Chile 1 <1%
United Kingdom 1 <1%
Italy 1 <1%
Unknown 154 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 24%
Researcher 39 24%
Professor > Associate Professor 16 10%
Student > Bachelor 14 8%
Professor 12 7%
Other 26 16%
Unknown 18 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 84 51%
Biochemistry, Genetics and Molecular Biology 43 26%
Medicine and Dentistry 8 5%
Chemistry 5 3%
Neuroscience 3 2%
Other 4 2%
Unknown 18 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2019.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Molecular Cell
#5,336
of 7,617 outputs
Outputs of similar age
#20,195
of 57,110 outputs
Outputs of similar age from Molecular Cell
#30
of 59 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,110 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.