Title |
Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances
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Published in |
Mediterranean Journal of Nutrition and Metabolism, December 2010
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DOI | 10.1007/s12349-010-0045-4 |
Pubmed ID | |
Authors |
Julien Cases, Alvin Ibarra, Nicolas Feuillère, Marc Roller, Samir G. Sukkar |
Abstract |
Botanicals are an alternative option to prescription drugs for the alleviation of symptoms due to anxiety disorders and insomnia. Melissa officinalis L. has been shown as an anti-stress and anxiolytic agent. We previously reported moderate stress improvement in mice in which Cyracos(®), a standardized Melissa officinalis L. extract, was administrated. Cyracos(®) contains phytochemicals that inhibit gamma-aminobutyric acid catabolism. This was a prospective, open-label, 15-day study to evaluate the efficacy of Cyracos(®) on stressed volunteers, who have mild-to-moderate anxiety disorders and sleep disturbances. Using clinician rating criteria, primary outcomes showed improvement of symptoms. Cyracos(®) reduced anxiety manifestations by 18% (p < 0.01), ameliorated anxiety-associated symptoms by 15% (p < 0.01) and lowered insomnia by 42% (p < 0.01). As much as 95% of subjects (19/20) responded to treatment, of which 70% (14/20) achieved full remission for anxiety, 85% (17/20) for insomnia, and 70% (14/20) for both. Our study demonstrates, for the first time that chronic administration of Melissa officinalis L. relieves stress-related effects. It is critical that further studies incorporate a placebo and investigate physiological stress markers. |
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United Kingdom | 2 | 18% |
New Zealand | 1 | 9% |
Australia | 1 | 9% |
Unknown | 3 | 27% |
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Scientists | 2 | 18% |
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Mendeley readers
Geographical breakdown
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Turkey | 1 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
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Researcher | 31 | 11% |
Student > Master | 25 | 9% |
Other | 19 | 7% |
Student > Doctoral Student | 17 | 6% |
Other | 32 | 12% |
Unknown | 74 | 27% |
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Unknown | 78 | 29% |