Title |
Replication Timing of Human Chromosome 6
|
---|---|
Published in |
Cell Cycle, October 2004
|
DOI | 10.4161/cc.4.1.1350 |
Pubmed ID | |
Authors |
Kathryn Woodfine, David M Beare, Koichi Ichimura, Silvana Debernardi, Andrew J Mungall, Heike Fiegler, V Peter Collins, Nigel P Carter, Ian Dunham |
Abstract |
Genomic microarrays have been used to assess DNA replication timing in a variety of eukaryotic organisms. A replication timing map of the human genome has already been published at a 1Mb resolution. Here we describe how the same method can be used to assess the replication timing of chromosome 6 with a greater resolution using an array of overlapping tile path clones. We report the replication timing map of the whole of chromosome 6 in general, and the MHC region in particular. Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity. |
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