| Title |
Linear-no-threshold is a radiation-protection standard rather than a mechanistic effect model
|
|---|---|
| Published in |
Radiation and Environmental Biophysics, February 2006
|
| DOI | 10.1007/s00411-006-0030-y |
| Pubmed ID | |
| Authors |
Joachim Breckow |
| Abstract |
The linear-no-threshold (LNT) controversy covers much more than the mere discussion whether or not "the LNT hypothesis is valid". It is shown that one cannot expect to find only one or even the only one dose-effect relationship. Each element within the biological reaction chain that is affected by ionizing radiation contributes in a specific way to the final biological endpoint of interest. The resulting dose-response relationship represents the superposition of all these effects. Till now there is neither a closed and clear picture of the entirety of radiation action for doses below some 10 mSv, nor does clear epidemiological evidence exist for an increase of risk for stochastic effects, in this dose range. On the other hand, radiation protection demands for quantitative risk estimates as well as for practicable dose concepts. In this respect, the LNT concept is preferred against any alternative concept. However, the LNT concept does not necessarily mean that the mechanism of cancer induction is intrinsically linear. It could hold even if the underlying multi-step mechanisms act in a non-linear way. In this case it would express a certain "attenuation" of non-linearities. Favouring LNT against threshold-, hyper-, or sub-linear models for radiation-protection purposes on the one hand, but preferring one of these models (e.g. for a specific effect) because of biological considerations for scientific purposes on the other hand, does not mean a contradiction. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 18% |
| Researcher | 6 | 18% |
| Other | 4 | 12% |
| Student > Bachelor | 3 | 9% |
| Student > Postgraduate | 3 | 9% |
| Other | 9 | 26% |
| Unknown | 3 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Physics and Astronomy | 8 | 24% |
| Medicine and Dentistry | 7 | 21% |
| Environmental Science | 2 | 6% |
| Neuroscience | 2 | 6% |
| Nursing and Health Professions | 2 | 6% |
| Other | 7 | 21% |
| Unknown | 6 | 18% |
Attention Score in Context
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#16,049,105
of 23,815,455 outputs
Outputs from Radiation and Environmental Biophysics
#331
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#135,849
of 158,697 outputs
Outputs of similar age from Radiation and Environmental Biophysics
#3
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