| Title |
HIF Inhibitors: Status of Current Clinical Development
|
|---|---|
| Published in |
Current Oncology Reports, January 2019
|
| DOI | 10.1007/s11912-019-0752-z |
| Pubmed ID | |
| Authors |
Jaleh Fallah, Brian I. Rini |
| Abstract |
In this review, the importance of the hypoxia inducible factor (HIF) pathway in tumorigenesis and cancer treatment outcomes will be discussed. The outcomes of phase II and III clinical trials of direct HIF inhibitors in the treatment of cancer will be reviewed. The HIF signaling pathway is activated by tumor-induced hypoxia or by inactivating mutations of the VHL gene. HIF is a transcription factor which regulates the expression of genes involved in adjusting mechanisms to hypoxia such as angiogenesis or apoptosis as well as tumor growth, invasion, and metastasis. The HIF pathway has a key role in development of resistance to different treatment modalities and higher expression of the HIF molecule is associated with poor prognosis. Clinical studies of the HIF inhibitors in patients with advanced/refractory cancers suggest benefit and warrant further studies of the HIF inhibitors either as a single agent or in combination with other therapeutic agents. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 64% |
| Spain | 1 | 7% |
| Italy | 1 | 7% |
| United Kingdom | 1 | 7% |
| Unknown | 2 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 43% |
| Practitioners (doctors, other healthcare professionals) | 5 | 36% |
| Scientists | 2 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 189 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 189 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 17% |
| Student > Master | 32 | 17% |
| Researcher | 21 | 11% |
| Student > Bachelor | 19 | 10% |
| Other | 11 | 6% |
| Other | 16 | 8% |
| Unknown | 57 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 48 | 25% |
| Medicine and Dentistry | 28 | 15% |
| Agricultural and Biological Sciences | 13 | 7% |
| Immunology and Microbiology | 9 | 5% |
| Chemistry | 8 | 4% |
| Other | 22 | 12% |
| Unknown | 61 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2023.
All research outputs
#1,598,064
of 24,220,739 outputs
Outputs from Current Oncology Reports
#32
of 944 outputs
Outputs of similar age
#38,670
of 445,417 outputs
Outputs of similar age from Current Oncology Reports
#2
of 27 outputs
Altmetric has tracked 24,220,739 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 944 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,417 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.