| Title |
Syndromes Predisposing to Pediatric Central Nervous System Tumors: Lessons Learned and New Promises
|
|---|---|
| Published in |
Current Neurology and Neuroscience Reports, December 2011
|
| DOI | 10.1007/s11910-011-0244-5 |
| Pubmed ID | |
| Authors |
Anita Villani, David Malkin, Uri Tabori |
| Abstract |
Central nervous system (CNS) neoplasms are a leading cause of morbidity and mortality among children with cancer. In contrast to adults, a genetic basis for brain tumors is relatively common in children. A child harboring a germline mutation in a cancer-related gene will be predisposed to develop CNS tumors. These cancer predisposition syndromes are rare but pose overwhelming clinical and psychosocial challenges to families and the treating team. Recent significant advances in our understanding of the biological processes that govern these genetic conditions combined with international efforts to define and treat clinical aspects of these tumors are transforming the lives of these individuals. In this article, we summarize recent progress made for each of the major CNS tumor syndromes. We discuss the biological and clinical relevance of such advances, and suggest a comprehensive approach to a child affected by a predisposition to brain tumors. |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 40 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 17% |
| Student > Doctoral Student | 6 | 14% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Master | 4 | 10% |
| Other | 4 | 10% |
| Other | 6 | 14% |
| Unknown | 10 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 36% |
| Agricultural and Biological Sciences | 6 | 14% |
| Psychology | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Environmental Science | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 11 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2023.
All research outputs
#4,958,728
of 23,770,218 outputs
Outputs from Current Neurology and Neuroscience Reports
#287
of 947 outputs
Outputs of similar age
#42,079
of 248,404 outputs
Outputs of similar age from Current Neurology and Neuroscience Reports
#5
of 9 outputs
Altmetric has tracked 23,770,218 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 947 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,404 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.