Title |
High content live cell imaging for the discovery of new antimalarial marine natural products
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Published in |
BMC Infectious Diseases, January 2012
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DOI | 10.1186/1471-2334-12-1 |
Pubmed ID | |
Authors |
Serena Cervantes, Paige E Stout, Jacques Prudhomme, Sebastian Engel, Matthew Bruton, Michael Cervantes, David Carter, Young Tae-Chang, Mark E Hay, William Aalbersberg, Julia Kubanek, Karine G Le Roch |
Abstract |
The human malaria parasite remains a burden in developing nations. It is responsible for up to one million deaths a year, a number that could rise due to increasing multi-drug resistance to all antimalarial drugs currently available. Therefore, there is an urgent need for the discovery of new drug therapies. Recently, our laboratory developed a simple one-step fluorescence-based live cell-imaging assay to integrate the complex biology of the human malaria parasite into drug discovery. Here we used our newly developed live cell-imaging platform to discover novel marine natural products and their cellular phenotypic effects against the most lethal malaria parasite, Plasmodium falciparum. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 4% |
Mexico | 1 | 1% |
Unknown | 66 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 24% |
Student > Ph. D. Student | 10 | 14% |
Student > Master | 6 | 9% |
Lecturer | 5 | 7% |
Other | 5 | 7% |
Other | 16 | 23% |
Unknown | 11 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 25 | 36% |
Chemistry | 9 | 13% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Medicine and Dentistry | 5 | 7% |
Engineering | 3 | 4% |
Other | 8 | 11% |
Unknown | 12 | 17% |