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Microscopic diffusivity compartmentation in formalin‐fixed prostate tissue

Overview of attention for article published in Magnetic Resonance in Medicine, December 2011
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1 X user
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1 patent

Citations

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35 Dimensions

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43 Mendeley
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1 CiteULike
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Title
Microscopic diffusivity compartmentation in formalin‐fixed prostate tissue
Published in
Magnetic Resonance in Medicine, December 2011
DOI 10.1002/mrm.23244
Pubmed ID
Authors

Roger M. Bourne, Nyoman Kurniawan, Gary Cowin, Timothy Stait‐Gardner, Paul Sved, Geoffrey Watson, William S. Price

Abstract

MR microimaging at 16.4 T with 40-μm isotropic voxels was used to investigate compartmentation of water diffusion in formalin-fixed prostate tissue. Ten tissue samples (~ 28 mm(3) each) from five organs were imaged. The mean diffusivity of epithelial, stromal, and ductal/acinar compartments was estimated by two methods: (1) manual region of interest selection and (2) Gaussian fitting of voxel diffusivity histograms. For the region of interest-method, the means of the tissue sample compartment diffusivities were significantly different (P < 0.001): 0.54 ± 0.05 μm(2)/ms for epithelium-containing voxels, 0.91 ± 0.17 μm(2)/ms for stroma, and 2.20 ± 0.04 μm(2)/ms for saline-filled ducts. The means from the histogram method were also significantly different (P < 0.001): 0.45 ± 0.08 μm(2)/ms for epithelium-containing voxels, 0.83 ± 0.16 μm(2)/ms for stroma, 2.21 ± 0.02 μm(2)/ms for duct. Estimated partial volumes of epithelial, stromal, and ductal/acinar compartments in a "tissue only" subvolume of each sample were significantly different (P < 0.02) between cancer and normal tissue for all three compartments. It is concluded that the negative correlation between apparent diffusion coefficient and cancer Gleason grade observed in vivo results from an increase of partial volume of epithelial tissue and concomitant decrease of stromal tissue and ductal space.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Germany 1 2%
Canada 1 2%
Unknown 40 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 35%
Student > Ph. D. Student 9 21%
Other 3 7%
Student > Doctoral Student 3 7%
Professor > Associate Professor 3 7%
Other 4 9%
Unknown 6 14%
Readers by discipline Count As %
Engineering 8 19%
Medicine and Dentistry 7 16%
Physics and Astronomy 6 14%
Agricultural and Biological Sciences 4 9%
Computer Science 3 7%
Other 5 12%
Unknown 10 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2019.
All research outputs
#7,071,674
of 24,590,593 outputs
Outputs from Magnetic Resonance in Medicine
#2,386
of 7,067 outputs
Outputs of similar age
#60,624
of 252,696 outputs
Outputs of similar age from Magnetic Resonance in Medicine
#52
of 98 outputs
Altmetric has tracked 24,590,593 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,067 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,696 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.