| Title |
The Warburg effect and its cancer therapeutic implications
|
|---|---|
| Published in |
Journal of Bioenergetics and Biomembranes, June 2007
|
| DOI | 10.1007/s10863-007-9086-x |
| Pubmed ID | |
| Authors |
Zhao Chen, Weiqin Lu, Celia Garcia-Prieto, Peng Huang |
| Abstract |
Increased aerobic glycolysis in cancer, a phenomenon known as the Warburg effect, has been observed in various tumor cells and represents a major biochemical alteration associated with malignant transformation. Although the exact molecular mechanisms underlying this metabolic change remain to be elucidated, the profound biochemical alteration in cancer cell energy metabolism provides exciting opportunities for the development of therapeutic strategies to preferentially kill cancer cells by targeting the glycolytic pathway. Several small molecules capable of inhibiting glycolysis in experimental systems have been shown to have promising anticancer activity in vitro and in vivo. This review article provides a brief summary of our current understanding of the Warburg effect, the underlying mechanisms, and its influence on the development of therapeutic strategies for cancer treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 1% |
| Portugal | 2 | <1% |
| United States | 2 | <1% |
| Malaysia | 1 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| Czechia | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 233 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 20% |
| Student > Bachelor | 41 | 17% |
| Researcher | 30 | 12% |
| Student > Master | 28 | 11% |
| Student > Doctoral Student | 17 | 7% |
| Other | 33 | 13% |
| Unknown | 46 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 66 | 27% |
| Biochemistry, Genetics and Molecular Biology | 39 | 16% |
| Medicine and Dentistry | 30 | 12% |
| Chemistry | 29 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Other | 19 | 8% |
| Unknown | 55 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2020.
All research outputs
#4,867,921
of 23,867,274 outputs
Outputs from Journal of Bioenergetics and Biomembranes
#44
of 466 outputs
Outputs of similar age
#13,325
of 72,056 outputs
Outputs of similar age from Journal of Bioenergetics and Biomembranes
#1
of 5 outputs
Altmetric has tracked 23,867,274 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 466 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 72,056 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them