| Title |
Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions
|
|---|---|
| Published in |
Molecular Neurobiology, December 2011
|
| DOI | 10.1007/s12035-011-8229-6 |
| Pubmed ID | |
| Authors |
Helgi B. Schiöth, Suzanne Craft, Samantha J. Brooks, William H. Frey, Christian Benedict |
| Abstract |
Insulin receptors in the brain are found in high densities in the hippocampus, a region that is fundamentally involved in the acquisition, consolidation, and recollection of new information. Using the intranasal method, which effectively bypasses the blood-brain barrier to deliver and target insulin directly from the nose to the brain, a series of experiments involving healthy humans has shown that increased central nervous system (CNS) insulin action enhances learning and memory processes associated with the hippocampus. Since Alzheimer's disease (AD) is linked to CNS insulin resistance, decreased expression of insulin and insulin receptor genes and attenuated permeation of blood-borne insulin across the blood-brain barrier, impaired brain insulin signaling could partially account for the cognitive deficits associated with this disease. Considering that insulin mitigates hippocampal synapse vulnerability to amyloid beta and inhibits the phosphorylation of tau, pharmacological strategies bolstering brain insulin signaling, such as intranasal insulin, could have significant therapeutic potential to deter AD pathogenesis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 50% |
| Canada | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| United States | 2 | 1% |
| Unknown | 167 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 17% |
| Student > Master | 29 | 17% |
| Researcher | 22 | 13% |
| Student > Bachelor | 13 | 8% |
| Student > Doctoral Student | 12 | 7% |
| Other | 37 | 22% |
| Unknown | 29 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 18% |
| Agricultural and Biological Sciences | 26 | 15% |
| Neuroscience | 24 | 14% |
| Biochemistry, Genetics and Molecular Biology | 13 | 8% |
| Psychology | 10 | 6% |
| Other | 25 | 15% |
| Unknown | 42 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 93. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2023.
All research outputs
#391,194
of 23,056,273 outputs
Outputs from Molecular Neurobiology
#22
of 3,492 outputs
Outputs of similar age
#2,138
of 245,173 outputs
Outputs of similar age from Molecular Neurobiology
#1
of 13 outputs
Altmetric has tracked 23,056,273 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,492 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,173 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.