| Title |
Intestinal Permeability in Irritable Bowel Syndrome Patients: Effects of NSAIDs
|
|---|---|
| Published in |
Digestive Diseases and Sciences, March 2009
|
| DOI | 10.1007/s10620-009-0765-9 |
| Pubmed ID | |
| Authors |
Angèle P. M. Kerckhoffs, Louis M. A. Akkermans, Martin B. M. de Smet, Marc G. H. Besselink, Falco Hietbrink, Imke H. Bartelink, Wim B. Busschers, Melvin Samsom, Willem Renooij |
| Abstract |
Intestinal permeability and the effect of NSAIDs on permeability were investigated in 14 irritable bowel syndrome (IBS) patients and 15 healthy subjects. In the study, 24-h urinary recoveries of orally administered polyethylene glycols (PEGs 400, 1500, and 4000) were not significantly different in healthy subjects and IBS patients before or after NSAID ingestion. Lactulose mannitol ratios in healthy subjects and IBS patients were not significantly different. Only time-dependent monitoring of PEG excretion showed that NSAIDs enhanced intestinal permeability for PEG 4000 in healthy subjects (P = 0.050) and for PEGs 400, 1500, and 4000 in IBS patients (P = 0.012, P = 0.041, and P = 0.012, respectively). These results show that intestinal permeability in IBS patients is not different from that in healthy subjects; NSAIDs compromise intestinal permeability in IBS patients to a greater extent than in healthy subjects, which suggests that IBS is associated with an altered response of the intestinal barrier to noxious agents. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 21% |
| Student > Bachelor | 12 | 18% |
| Student > Master | 12 | 18% |
| Other | 6 | 9% |
| Student > Postgraduate | 6 | 9% |
| Other | 12 | 18% |
| Unknown | 6 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 26% |
| Biochemistry, Genetics and Molecular Biology | 9 | 13% |
| Agricultural and Biological Sciences | 9 | 13% |
| Nursing and Health Professions | 7 | 10% |
| Immunology and Microbiology | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 13 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2019.
All research outputs
#5,017,235
of 23,854,458 outputs
Outputs from Digestive Diseases and Sciences
#738
of 4,304 outputs
Outputs of similar age
#18,800
of 95,783 outputs
Outputs of similar age from Digestive Diseases and Sciences
#4
of 19 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,304 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,783 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.