| Title |
Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, April 2011
|
| DOI | 10.1007/s10803-011-1260-7 |
| Pubmed ID | |
| Authors |
Stepan Melnyk, George J. Fuchs, Eldon Schulz, Maya Lopez, Stephen G. Kahler, Jill J. Fussell, Jayne Bellando, Oleksandra Pavliv, Shannon Rose, Lisa Seidel, David W. Gaylor, S. Jill James |
| Abstract |
Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 17% |
| United States | 2 | 17% |
| Canada | 1 | 8% |
| Côte d'Ivoire | 1 | 8% |
| Unknown | 6 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 83% |
| Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Ireland | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Israel | 1 | <1% |
| Unknown | 188 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 32 | 16% |
| Student > Ph. D. Student | 26 | 13% |
| Student > Master | 24 | 12% |
| Student > Bachelor | 23 | 12% |
| Other | 16 | 8% |
| Other | 38 | 19% |
| Unknown | 37 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 18% |
| Biochemistry, Genetics and Molecular Biology | 27 | 14% |
| Agricultural and Biological Sciences | 24 | 12% |
| Neuroscience | 15 | 8% |
| Psychology | 13 | 7% |
| Other | 40 | 20% |
| Unknown | 42 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2023.
All research outputs
#1,432,697
of 24,853,509 outputs
Outputs from Journal of Autism and Developmental Disorders
#557
of 5,390 outputs
Outputs of similar age
#5,630
of 115,097 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#6
of 48 outputs
Altmetric has tracked 24,853,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,390 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 115,097 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.