| Title |
Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the 13C-acetate breath test
|
|---|---|
| Published in |
Journal of Neurology, January 2012
|
| DOI | 10.1007/s00415-011-6372-7 |
| Pubmed ID | |
| Authors |
Yuji Tanaka, Tomohiro Kato, Hiroshi Nishida, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Hiroshi Araki, Masahiko Murase, Masahito Nagaki, Hisataka Moriwaki, Takashi Inuzuka |
| Abstract |
Autonomic failure is one of the criteria according to the second consensus statement for the diagnosis of multiple system atrophy (MSA). Gastrointestinal symptoms are frequent complaints in patients with MSA and may be associated with reduced gastrointestinal motility due to autonomic nervous system dysfunction. However, there are few reports on gastric emptying in patients with MSA. We investigated gastric emptying in 25 patients with MSA, 20 patients with sporadic adult-onset ataxia of unknown etiology (SAOA), and 20 healthy volunteers using the (13)C-acetate breath test. Gastric emptying function is estimated by this test as the half-emptying time (HET) and peak time of the (13)C-%-dose-excess curve (T (max)), with expirations collected for 4 h after a test meal and determination of (13)CO(2) content using an infrared (IR) spectrophotometer. The HET and T (max) of gastric emptying were significantly delayed in patients with MSA as compared to those in SAOA and controls (p < 0.01). The HET and T (max) were not significantly different between SAOA and controls. No correlation existed between the HET or T (max) and the duration or severity of the disease in MSA patients. These results suggested that gastric emptying was significantly delayed in patients with MSA, and the delay already appeared in the early stage of the disease. Delayed gastric emptying is one of the autonomic failures and may be a clinical marker of MSA. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 22% |
| Student > Bachelor | 2 | 11% |
| Lecturer | 1 | 6% |
| Student > Master | 1 | 6% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 9 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 17% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Neuroscience | 1 | 6% |
| Social Sciences | 1 | 6% |
| Unknown | 11 | 61% |
Attention Score in Context
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#18,303,566
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Outputs of similar age from Journal of Neurology
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