| Title |
Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer
|
|---|---|
| Published in |
Tumor Biology, January 2012
|
| DOI | 10.1007/s13277-011-0308-9 |
| Pubmed ID | |
| Authors |
Reo Maruyama, Hiromu Suzuki, Eiichiro Yamamoto, Kohzoh Imai, Yasuhisa Shinomura |
| Abstract |
Epigenetic changes, including DNA methylation and histone modification, play key roles in the dysregulation of tumor-related genes, thereby affecting numerous cellular processes, including cell proliferation, cell adhesion, apoptosis, and metastasis. In recent years, numerous studies have shown that noncoding RNAs (ncRNAs) are key players in the initiation and progression of cancer and epigenetic mechanisms are deeply involved in their dysregulation. Indeed, the growing list of microRNA (miRNA) genes aberrantly methylated in cancer suggests that a large number of miRNAs exert tumor-suppressive or oncogenic effects. In addition, it now appears that long ncRNAs may be causally related to epigenetic dysregulation of critical genes in cancer. Dissection of the relationships between ncRNAs and epigenetic alterations may lead to the development of novel approaches to the diagnosis and treatment of cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 2% |
| Belgium | 1 | 2% |
| Unknown | 44 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 26% |
| Researcher | 11 | 24% |
| Student > Master | 5 | 11% |
| Student > Postgraduate | 4 | 9% |
| Student > Bachelor | 4 | 9% |
| Other | 7 | 15% |
| Unknown | 3 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 39% |
| Medicine and Dentistry | 12 | 26% |
| Biochemistry, Genetics and Molecular Biology | 6 | 13% |
| Chemistry | 2 | 4% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 4 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2019.
All research outputs
#4,484,032
of 22,661,413 outputs
Outputs from Tumor Biology
#134
of 2,620 outputs
Outputs of similar age
#38,736
of 243,401 outputs
Outputs of similar age from Tumor Biology
#3
of 18 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,620 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,401 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.